Cobalt oxide modified screen-printed carbon electrode for electrochemical detection of high blood pressure treating drug: reserpine.

Abstract

This study presents the development of a cobalt oxide-modified screen-printed carbon electrode (CoO/SPCE) for the electrochemical detection of reserpine (RES), a drug used to treat high blood pressure. The CoO/SPCE was fabricated using an optimized electrodeposition method, resulting in a sensitive and reproducible platform for RES detection. Electrochemical characterization demonstrated that the CoO/SPCE exhibited superior electrocatalytic activity, as evidenced by a notable increase in oxidation peak current compared to bare and activated SPCEs. The electrode showed a linear response to RES concentrations ranging from 2 to 100 μM with a detection limit of 1.08 μM. Additionally, the sensor demonstrated good stability and reproducibility with relative standard deviations (RSDs) of 5.11% and 2.72%, respectively. This work highlights the CoO/SPCE's potential for practical pharmaceutical analysis, offering a novel approach to enhancing the sensitivity and reliability of electrochemical sensors for drug monitoring.