Rory J Lubner, Mason Krysinski, Ping Li, Rakesh K Chandra, Justin H Turner, Naweed I Chowdhury
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引用次数: 0
Abstract
Background: Particulate matter ⩽2.5 µm in diameter (PM2.5) and its role in chronic rhinosinusitis (CRS) pathogenesis have gained heightened attention. We previously demonstrated that PM2.5 exposure may bias the nasal mucosa in CRS toward a Type 2 inflammatory pathway. However, there are limited data comparing cytokine changes in CRS sinonasal tissue to non-CRS patients as it relates to PM2.5 exposure. We hypothesized that long-term exposure preferentially increases the risk of manifesting CRS with nasal polyposis (CRSwNP).
Methods: We performed a retrospective analysis of 376 patients (308 CRS, 68 controls) who underwent endoscopic sinus or skull base surgery. A spatiotemporal machine-learning model estimated daily PM2.5 levels for 1 year prior to each patient's surgery date. Cytokines were quantified using a multiplex flow cytometric bead assay and compared to estimated PM2.5 exposure using Spearman correlation and multivariate regression. Patients with high and low 12-month PM2.5 exposures were matched across age, sex, income, and rurality using a nearest neighbor algorithm. Multivariate adjusted logistic regression was used to estimate the odds of CRS based on PM2.5 exposure.
Results: Reduced IL-10 levels were associated with higher PM2.5 exposures in control patients (β = -0.735, p = 0.0196). In exposure-matched logistic regression analysis, high 12-month PM2.5 exposure was an independent predictor of CRSwNP (β = 1.97, OR: 7.22, p = 0.0001) after adjustment for age, income, rurality, and comorbid asthma/allergic rhinitis. A similar relationship was not identified for CRSsNP.
Conclusions: PM2.5 exposure is associated with reduced IL-10 in control patients compared to CRS and may increase odds of CRSwNP development.
期刊介绍：
International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy.
International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.
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