{"title":"Extramedullary dissemination in multiple myeloma: a case report of rare leptomeningeal involvement and comprehensive treatment outcomes.","authors":"Tanya Stoeva, Zhivka Dancheva, Sofiya Chausheva, Tsvetelina Yordanova, Borislav Chaushev, Aneliya Klisarova","doi":"10.3897/folmed.67.e132922","DOIUrl":null,"url":null,"abstract":"<p><p>Multiple myeloma (MM) is a clonal plasma cell malignancy often confined to the bone marrow, although extramedullary disease (EMD) can develop, especially in advanced or relapsed cases. Leptomeningeal EMD is a rare and aggressive manifestation associated with a dismal prognosis. This case report highlights the critical role of 18F-FDG PET/CT in managing such complex presentations.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Folia medica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3897/folmed.67.e132922","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Dentistry","Score":null,"Total":0}
引用次数: 0
Abstract
Multiple myeloma (MM) is a clonal plasma cell malignancy often confined to the bone marrow, although extramedullary disease (EMD) can develop, especially in advanced or relapsed cases. Leptomeningeal EMD is a rare and aggressive manifestation associated with a dismal prognosis. This case report highlights the critical role of 18F-FDG PET/CT in managing such complex presentations.
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