Effect of Serum IgE on Clinical Variables and Comorbidities Associated with Asthma Severity in Adults with Asthma in Brooklyn, New York.

IF 1.1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Annals of clinical and laboratory science Pub Date : 2025-03-01

Tamar A Smith-Norowitz, Yecheskel Gold, Esther M Norowitz, Rauno Joks, Stephan Kohlhoff

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引用次数: 0

Abstract

Objective: Elevated serum immunoglobulin (Ig)E levels are associated with increased asthma and atopy severity in adults. The aim of this study was to determine whether levels of serum IgE or allergic sensitization affected clinical variables and increased the risk of asthma severity in adults with asthma in Brooklyn, NY.

Methods: Retrospective study of adults with moderate asthma and atopy (N=66, mean age 49+/-14 y/o, 75% female). The primary analysis assessed the relationship between total serum IgE, presence of specific IgE (skin prick test), and clinical variables (body mass index (BMI) and pulmonary function tests). Data preparation and analysis was conducted using SPSS (Version 28.0.1.1).

Results: Subjects with elevated total serum IgE had higher levels of pulmonary obstruction/asthma severity (FEV1/FVC, mean difference: -5.62±3.4, P=0.05 and FEF25-75, mean difference: 15.49±9.5, P= 0.05) (T-test for equality of means). Mean BMI was higher in subjects with allergic sensitization versus those without (32.59±8.14 vs. 29.5±4.4, P=0.05).

Conclusion: In adults with asthma there was a trend observed toward an association of atopy with clinical variables, including decreased lung function and higher BMI. The presence of high serum IgE levels should be considered when assessing asthma outcomes.

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血清IgE对纽约布鲁克林成人哮喘患者哮喘严重程度相关临床变量和合并症的影响

目的：成人血清免疫球蛋白（Ig）E水平升高与哮喘和特应性严重程度增加有关。本研究的目的是确定血清IgE水平或过敏致敏是否会影响临床变量，并增加纽约布鲁克林成人哮喘患者哮喘严重程度的风险。方法：回顾性研究中度哮喘合并特应性成人66例，平均年龄49+/-14岁，75%为女性。初步分析评估了血清总IgE、特异性IgE的存在（皮肤点刺试验）和临床变量（体重指数（BMI）和肺功能试验）之间的关系。使用SPSS（28.0.1.1版）进行数据准备和分析。结果：血清总IgE升高的受试者有较高的肺阻塞/哮喘严重程度（FEV1/FVC，平均差值为-5.62±3.4，P=0.05）和FEF25-75，平均差值为15.49±9.5，P=0.05) （t检验均数相等）。过敏致敏组的BMI平均值高于无过敏致敏组（32.59±8.14∶29.5±4.4，P=0.05）。结论：在成人哮喘患者中，观察到特应性与临床变量（包括肺功能下降和BMI升高）相关的趋势。在评估哮喘结果时应考虑血清IgE水平过高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of clinical and laboratory science 医学-医学实验技术

CiteScore

1.60

自引率

0.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： The Annals of Clinical & Laboratory Science welcomes manuscripts that report research in clinical science, including pathology, clinical chemistry, biotechnology, molecular biology, cytogenetics, microbiology, immunology, hematology, transfusion medicine, organ and tissue transplantation, therapeutics, toxicology, and clinical informatics.