Association between HIV and cancer risk.

IF 3.1 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2025-08-01 Epub Date: 2025-04-14 DOI:10.1097/QAD.0000000000004210

Tak Kyu Oh, Kyoung-Ho Song, Eunjeong Heo, In-Ae Song

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引用次数: 0

Abstract

Objective: We aimed to examine whether people with HIV infection (PWH) show different cancer incidences compared to individuals without HIV infection in South Korea.

Design: Population-based cohort study.

Methods: This study included all PWH diagnosed with HIV infections in South Korea between 1 January 2017 and 31 December 2017. The 2017 PWH number includes both new and previous HIV diagnoses. The prevalence of newly diagnosed AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) were evaluated from 1 January 2018 to 31 December 2022, as endpoints.

Results: Following 1 : 5 propensity score matching, 20 703 PWH and 89 881 controls were included. The incidence rate of ADCs was 165.9 per 100 000 person-years in PWH and 51.8 per 100 000 person-years in the controls. In the Cox regression analysis, PWH had a 3.17-fold higher incidence of ADCs than in the controls (hazard ratio: 3.17, 95% confidence interval: 2.60-3.86; P < 0.001). The incidence rate of NADCs was 1614 per 100 000 person-years in PWH and 1888 per 100 000 person-years in the controls. In the Cox regression analysis, no significant difference was observed in the incidence of NADCs between PWH and the control group ( P = 0.101). However, PWH showed a higher incidence of NADCs than in the controls for nasopharyngeal, anal, and nonmelanoma skin cancers; Hodgkin lymphoma; and, leukemia.

Conclusion: PWH had a greater risk of ADCs than individuals without HIV infection. Among the NADCs, PWH showed a greater risk of nasopharyngeal, anal, nonmelanoma skin cancers; Hodgkin lymphoma; and leukemia.

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HIV和癌症风险之间的关系：一项全国性的、基于人群的队列研究。

目的：我们旨在研究韩国人类免疫缺陷病毒（HIV）感染（PLWH）的人与未感染HIV的人相比是否有不同的癌症发病率。设计：基于人群的队列研究。方法：本研究纳入了2017年1月1日至2017年12月31日期间在韩国诊断为HIV感染的所有PLWH。2017年艾滋病毒感染者死亡人数包括新的和以前的艾滋病毒诊断。以2018年1月1日至2022年12月31日为终点，评估新诊断的获得性免疫缺陷综合征（AIDS）定义癌（adc）和非艾滋病定义癌（NADCs）的患病率。结果：按照1:5倾向评分匹配，纳入20,703名PLWH和89,881名对照。adc的发病率在PLWH组为165.9 / 10万人-年，对照组为51.8 / 10万人-年。Cox回归分析显示，PLWH组adc发生率比对照组高3.17倍(风险比：3.17,95%可信区间：2.60,3.86；结论：艾滋病患者发生adc的风险高于未感染HIV的人群。在NADCs中，PLWH显示鼻咽癌、肛门癌和非黑色素瘤皮肤癌的风险更高；霍奇金淋巴瘤;白血病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.