Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects.

IF 2.7 3区生物学

Hereditas Pub Date : 2025-05-11 DOI:10.1186/s41065-025-00443-2

Fan Yang, Qiuxia Qin, Juan Liu

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引用次数: 0

Abstract

Aim: The present study was conducted with the objective ascertaining the clinical implication of microRNA-133a-3p (miR-133a-3p) for urinary incontinence (UI) and rehabilitation effects in prostate cancer after radical prostatectomy.

Methods: The measurements of miR-133a-3p in urethral tissue samples from prostate cancer patients after radical prostatectomy were carried out via quantitative real-time polymerase chain reaction (qRT-PCR) detection. Receiver operation characteristic (ROC) curve and logistic regression analysis were employed for evaluating the predictive significance of miR-133a-3p for the early UI of prostate cancer patients with radical prostatectomy. Bioinformatics tools were employed for mining the miR-133a-3p possible genes.

Results: An obvious reduction of miR-133a-3p was detected in patients with UI compared with those with urinary continence (UC) (P < 0.001), demonstrating a high diagnostic capacity for patients with UI. Moreover, miR-133a-3p could be an independent predictive index for the early UI in patients with prostate cancer after radical prostatectomy (P < 0.001). Additionally, urine miR-133a-3p was notably increased in the UI patients after rehabilitation (P < 0.001). MiR-133a-3p largely concentered on the muscle-related diseases pathways using bioinformatics tools.

Conclusion: MiR-133a-3p was a promising indicator for predicting early UI in patients with prostate cancer after radical prostatectomy.

Clinical trial number: Not applicable.

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microRNA-133a-3p对前列腺癌根治性前列腺切除术后早期尿失禁的预测价值及其与康复效果的相关性

目的：本研究旨在确定microRNA-133a-3p （miR-133a-3p）在前列腺癌根治性前列腺切除术后尿失禁（UI）及康复效果中的临床意义。方法：采用实时定量聚合酶链反应（qRT-PCR）检测前列腺癌根治性前列腺切除术后患者尿道组织样本中miR-133a-3p的含量。采用受试者操作特征（ROC）曲线和logistic回归分析评价miR-133a-3p对前列腺癌根治性前列腺切除术患者早期UI的预测意义。利用生物信息学工具挖掘miR-133a-3p可能的基因。结果：与尿失禁（UC）患者相比，尿失禁患者的miR-133a-3p水平明显降低(P结论：miR-133a-3p是预测前列腺癌根治性前列腺切除术后早期尿失禁的一个有希望的指标。临床试验号：不适用。

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来源期刊

Hereditas Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.80

自引率

3.70%

发文量

期刊介绍： For almost a century, Hereditas has published original cutting-edge research and reviews. As the Official journal of the Mendelian Society of Lund, the journal welcomes research from across all areas of genetics and genomics. Topics of interest include human and medical genetics, animal and plant genetics, microbial genetics, agriculture and bioinformatics.