Exploring Potential Health Risk of Chenxiang Huaqi Tablets Based on Inorganic Elemental Evaluation Using ICP-MS.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biological Trace Element Research Pub Date : 2025-04-29 DOI:10.1007/s12011-025-04642-w

Shuxiang Pan, Lin Yang, Yiwu Wang, Yuan Shen, Jialing Yu, Dan He

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引用次数: 0

Abstract

Chenxiang Huaqi Tablet (CXHQT) is a Chinese patent medicine preparation composed of 10 traditional Chinese herbs. In this study, the concentrations of 23 inorganic elements in CXHQT were determined by inductively coupled plasma mass spectrometry (ICP-MS). The fingerprint of the elements was established, the chemometrics and element correlation analysis were carried out, and the health risk assessment of heavy metals and harmful elements was performed. The results revealed that there were certain differences in the content of inorganic elements in 15 batches of CXHQT manufactured by the same pharmaceutical company. Pb, U, Al, Ga, Cd, As, Co, Ni, and Fe were identified as characteristic elements contributing to quality differences by chemometric analysis. In addition, the results of health risk assessment, such as total hazard index (HI) and total carcinogenic risk (TCR), indicated that the content of Al, Cr, Mn, Co, Ni, Cu, Zn, As, Sr, Cd, and Pb in CXHQT was within the normal range and would not endanger human health. This study provided a scientific and comprehensive reference for evaluation of inorganic elements and safety in CXHQT.

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基于ICP-MS法评价陈香化气片的潜在健康风险

陈香化气片（CXHQT）是由10种中草药组成的中成药制剂。本研究采用电感耦合等离子体质谱法（ICP-MS）测定CXHQT中23种无机元素的浓度。建立元素指纹图谱，进行化学计量学和元素相关性分析，进行重金属和有害元素健康风险评价。结果发现，同一制药公司生产的15批CXHQT中，无机元素含量存在一定差异。通过化学计量分析，确定了Pb、U、Al、Ga、Cd、As、Co、Ni和Fe是导致品质差异的特征元素。此外，总危害指数（HI）和总致癌风险（TCR）等健康风险评估结果表明，CXHQT中Al、Cr、Mn、Co、Ni、Cu、Zn、as、Sr、Cd、Pb的含量均在正常范围内，不会危害人体健康。本研究为CXHQT中无机元素含量及安全性评价提供了科学、全面的参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Trace Element Research 生物-内分泌学与代谢

CiteScore

8.70

自引率

10.30%

发文量

459

审稿时长

2 months

期刊介绍： Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.