Targeting ferroptosis for precision medicine in cervical cancer.

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Apoptosis Pub Date : 2025-05-07 DOI:10.1007/s10495-025-02120-1

Xin Sun, Zhuoxi Chen, Hui Yang, Jianing Yu, Haiyan Lin, Leiming Zhang

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Abstract

Cervical cancer (CC) is a prevalent malignant tumor in the female reproductive system, with rising incidence rates among younger women posing a significant public health challenge. Human papillomavirus (HPV) infection is the primary cause, driving carcinogenesis by promoting abnormal proliferation of tumor cells. Ferroptosis is a form of regulated necrosis that is caused by an iron-dependent accumulation of lipid peroxides with rupture of the plasma membrane. Targeting ferroptosis-related molecules and pathways can selectively induce cervical cancer cell death, while alterations in the expression of ferroptosis-related genes provide promising biomarkers for prognostic assessment. Advances in research on biomarkers and molecular targets are improving predictions of therapeutic outcomes, overcoming drug resistance, and optimizing immunotherapy strategies, thereby opening new avenues for precision medicine. This review focuses on the molecular mechanisms underlying ferroptosis in cervical cancer, discusses its potential applications in early diagnosis and prognosis evaluation, and summarizes the latest advancements in targeted therapy, aiming to provide a novel perspective for the clinical management of cervical cancer.

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靶向铁下垂在宫颈癌精准医疗中的应用。

宫颈癌（CC）是女性生殖系统中一种常见的恶性肿瘤，在年轻女性中发病率不断上升，对公共卫生构成重大挑战。人乳头瘤病毒（HPV）感染是主要原因，通过促进肿瘤细胞的异常增殖来驱动癌变。铁下垂是一种受调节的坏死形式，是由铁依赖性脂质过氧化物积累与质膜破裂引起的。靶向铁中毒相关分子和途径可以选择性诱导宫颈癌细胞死亡，而铁中毒相关基因表达的改变为预后评估提供了有希望的生物标志物。生物标志物和分子靶点的研究进展正在改善治疗结果的预测，克服耐药性，优化免疫治疗策略，从而为精准医学开辟新的途径。本文综述了宫颈癌铁下垂的分子机制，探讨了其在早期诊断和预后评估中的潜在应用，并总结了靶向治疗的最新进展，旨在为宫颈癌的临床治疗提供新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Apoptosis 生物-生化与分子生物学

CiteScore

9.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.