Transcriptomic analysis of the TRP gene family in human brain physiopathology.

IF 3.5 3区医学 Q2 NEUROSCIENCES

Frontiers in Molecular Neuroscience Pub Date : 2025-04-24 eCollection Date: 2025-01-01 DOI:10.3389/fnmol.2025.1576941

Barbara Olejniczak, Arpita Balakrishnan, Justyna Augustyniak, Elżbieta Salińska, Agnieszka Bronisz, Jakub Godlewski

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Abstract

The transient receptor potential (TRP) gene family is vital to cellular physiology, mediating ion flow across membranes and facilitating sensory signal transduction. This article examines the transcriptomic landscape of TRP genes, emphasizing their varying expression across organs, tissues, and cells, with a particular focus on the brain. Analysis reveals a distinct spatial distribution of TRP gene expression, notably enriched in the hippocampus during brain development, highlighting their essential role in neuronal function. Utilizing datasets from the Human Protein Atlas, Allen Human Brain Atlas, and studies on aging and dementia, associations are identified between TRP gene expression and the development or pathophysiology of neural tissue, highlighting the therapeutic potential of TRP channels in addressing, e.g., sensory impairments and cognitive decline. These insights into the regulatory dynamics of TRP channels lay a foundation for developing targeted interventions for neurodegenerative disorders.

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TRP基因家族在人脑生理病理中的转录组学分析。

瞬时受体电位（TRP）基因家族对细胞生理至关重要，介导离子跨膜流动和促进感觉信号转导。本文研究了TRP基因的转录组学景观，强调了它们在器官、组织和细胞中的不同表达，特别关注于大脑。分析表明，TRP基因表达具有明显的空间分布，特别是在大脑发育过程中在海马中富集，突出了其在神经元功能中的重要作用。利用来自人类蛋白质图谱、艾伦人脑图谱以及衰老和痴呆研究的数据集，确定了TRP基因表达与神经组织发育或病理生理之间的关联，突出了TRP通道在解决感觉障碍和认知能力下降等问题方面的治疗潜力。这些对TRP通道调控动态的见解为开发针对神经退行性疾病的靶向干预奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Molecular Neuroscience NEUROSCIENCES-

CiteScore

5.70

自引率

2.10%

发文量

669

审稿时长

14 weeks

期刊介绍： Frontiers in Molecular Neuroscience is a first-tier electronic journal devoted to identifying key molecules, as well as their functions and interactions, that underlie the structure, design and function of the brain across all levels. The scope of our journal encompasses synaptic and cellular proteins, coding and non-coding RNA, and molecular mechanisms regulating cellular and dendritic RNA translation. In recent years, a plethora of new cellular and synaptic players have been identified from reduced systems, such as neuronal cultures, but the relevance of these molecules in terms of cellular and synaptic function and plasticity in the living brain and its circuits has not been validated. The effects of spine growth and density observed using gene products identified from in vitro work are frequently not reproduced in vivo. Our journal is particularly interested in studies on genetically engineered model organisms (C. elegans, Drosophila, mouse), in which alterations in key molecules underlying cellular and synaptic function and plasticity produce defined anatomical, physiological and behavioral changes. In the mouse, genetic alterations limited to particular neural circuits (olfactory bulb, motor cortex, cortical layers, hippocampal subfields, cerebellum), preferably regulated in time and on demand, are of special interest, as they sidestep potential compensatory developmental effects.