Psychiatric disorders, impulsivity and borderline personality in patients with polycystic ovary syndrome.

IF 3.2 3区医学 Q2 PSYCHIATRY

Archives of Women's Mental Health Pub Date : 2025-05-06 DOI:10.1007/s00737-025-01589-8

Mariwan Husni, Diaa E E Rizk, Nawal Saad Alabdulla, Aldana Zayed, Hosni Malas, Nourah Adbulaziz Modahka, Sabeeka Jamal Alqujan, Basma Khalid Alansari, Shaika Ebrahim Alhajri, Nada Mahmood, Haitham Jahrami

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引用次数: 0

Abstract

Introduction: Polycystic ovarian syndrome (PCOS) is a common endocrine condition in women. Studies have shown that PCOS is associated with poor quality of life, anxiety, sadness, dissatisfaction with one's appearance, and sexual dysfunction.

Objective: This study was conducted to determine whether a strong psycho-pathological personality is related to PCOS and whether this personality is related to the hyperandrogenic state.

Methods: Anthropometric, metabolic, hormonal, clinical, and psychological characteristics were examined in 90 Bahraini women with PCOS. After confirming the diagnosis of PCOS via Rotterdam criteria, including ovarian ultrasound, each patient was evaluated via the following questionnaires: 1) the GAD-7 (General Anxiety Disorder-7) to measure the severity of anxiety; 2) the Patient Health Questionnaire-9 (PHQ-9) to confirm and measure the severity of depression; 3) the Barratt Impulsiveness Scale (BIS-11) to measure aggression; and 4) the McLean Screening Instrument to identify borderline personality disorders (MSI-BPDs). The study was approved by the Institutional Review Board.

Results: Compared to controls, PCOS patients exhibited significantly higher rates of severe depression (8% vs. 0%, p < 0.001), severe anxiety (7% vs. 0%, p < 0.001), impulsivity (BIS-11: 39.43 ± 9.69 vs. 26.64 ± 2.92, p < 0.001), and borderline personality traits (McLean: 2.41 ± 2.44 vs. 1.2 ± 0.94, p < 0.001). Metabolic comorbidities, including obesity (BMI 28.88 vs. 20.27, p < 0.001) and hypothyroidism (48% vs. 0%, p < 0.001), were prevalent in PCOS. Hyperandrogenism correlated weakly with psychiatric outcomes (all p > 0.05).

Conclusion: Women with PCOS demonstrate markedly elevated psychiatric and medical burdens compared to healthy controls. While hyperandrogenism showed limited direct associations, metabolic dysfunction (e.g., obesity) may mediate psychiatric risk. These findings underscore the need for multidisciplinary care integrating psychological and endocrine management, particularly in populations where cultural norms exacerbate PCOS-related distress.

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多囊卵巢综合征患者的精神障碍、冲动和边缘型人格。

简介：多囊卵巢综合征（PCOS）是一种常见的女性内分泌疾病。研究表明，多囊卵巢综合征与生活质量差、焦虑、悲伤、对自己的外表不满和性功能障碍有关。目的：探讨强烈的心理病理人格是否与PCOS有关，以及这种人格是否与高雄激素状态有关。方法：对90例巴林多囊卵巢综合征（PCOS）患者进行人体测量、代谢、激素、临床和心理特征的检测。经包括卵巢超声检查在内的鹿特丹标准确诊PCOS后，通过以下问卷对患者进行评估：1)GAD-7 (General Anxiety Disorder-7)，衡量焦虑的严重程度；2)采用患者健康问卷-9 （PHQ-9）确认和测量抑郁的严重程度；3) Barratt冲动性量表（BIS-11）测量攻击性；4)边缘型人格障碍（msi - bpd）的McLean筛查工具。这项研究得到了机构审查委员会的批准。结果：与对照组相比，PCOS患者表现出明显更高的严重抑郁发生率（8%比0%，p 0.05）。结论：与健康对照相比，PCOS患者的精神和医疗负担明显增加。虽然高雄激素血症显示有限的直接关联，但代谢功能障碍（如肥胖）可能介导精神风险。这些发现强调了综合心理和内分泌管理的多学科护理的必要性，特别是在文化规范加剧多囊卵巢综合征相关痛苦的人群中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Women's Mental Health 医学-精神病学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Archives of Women’s Mental Health is the official journal of the International Association for Women''s Mental Health, Marcé Society and the North American Society for Psychosocial Obstetrics and Gynecology (NASPOG). The exchange of knowledge between psychiatrists and obstetrician-gynecologists is one of the major aims of the journal. Its international scope includes psychodynamics, social and biological aspects of all psychiatric and psychosomatic disorders in women. The editors especially welcome interdisciplinary studies, focussing on the interface between psychiatry, psychosomatics, obstetrics and gynecology. Archives of Women’s Mental Health publishes rigorously reviewed research papers, short communications, case reports, review articles, invited editorials, historical perspectives, book reviews, letters to the editor, as well as conference abstracts. Only contributions written in English will be accepted. The journal assists clinicians, teachers and researchers to incorporate knowledge of all aspects of women’s mental health into current and future clinical care and research.