Clinical and patient-reported outcomes of self-administered outpatient parenteral antimicrobial treatment (S-OPAT): a scoping review.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES

Infection Pub Date : 2025-05-12 DOI:10.1007/s15010-025-02549-1

Jolanda M Maaskant, Tessa de Vries, Laura Volle, Faridi S Jamaludin, Suzanne E Geerlings, Kim C E Sigaloff

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引用次数: 0

Abstract

Purpose: This study aimed to provide a comprehensive overview of the existing literature on Self-administered Outpatient Parenteral Antimicrobial Therapy (S-OPAT), focusing on safety and clinical outcomes, factors influencing these outcomes, and the experiences of patients and caregivers.

Methods: We searched the databases MEDLINE, CINAHL, Embase and Cochrane library. Publications were included if they reported on the clinical outcomes, safety, and/or experiences of patients and caregivers with S-OPAT. Study selection and data extraction were performed independently by two reviewers. Quantitative and qualitative data were summarized in data charting forms.

Results: Forty-four studies were included: 41 primary studies, 2 systematic reviews and 1 clinical guideline. Clinical outcomes were reported in 17 and safety in 23 primary studies. Eleven studies compared S-OPAT to other OPAT delivery models. These studies showed that all models were generally comparable regarding clinical outcomes, but two studies reported an increased number of adverse events with S-OPAT. Nine studies, exploring a total of 7 potential risk factors, identified older age, comorbidities and Staphylococcus aureus infections as contributors to adverse events. The results of 14 studies on patient-centred outcomes showed that patients and caregivers considered S-OPAT a suitable alternative to other OPAT delivery models.

Conclusion: We conclude that S-OPAT is a viable model of care, demonstrating favourable clinical outcomes, although some safety concerns have been reported. The growing care demand now and in the future urges further development of S-OPAT care. Gaps of knowledge still exist, and we provide recommendations for future research.

查看原文本刊更多论文

门诊患者自行给予肠外抗菌药物治疗（S-OPAT）的临床和患者报告结果：一项范围审查。

目的：本研究旨在全面概述现有关于自我给药门诊静脉注射抗菌药物治疗（S-OPAT）的文献，重点关注安全性和临床结果、影响这些结果的因素以及患者和护理人员的经验。方法：检索MEDLINE、CINAHL、Embase、Cochrane等数据库。如果出版物报道了S-OPAT患者和护理人员的临床结果、安全性和/或经验，则将其纳入。研究选择和数据提取由两位评论者独立完成。定量和定性数据以数据图表形式汇总。结果：共纳入44项研究：41项初步研究，2项系统综述，1项临床指南。17项初步研究报告了临床结果，23项初步研究报告了安全性。11项研究比较了S-OPAT与其他OPAT交付模式。这些研究表明，在临床结果方面，所有模型总体上具有可比性，但有两项研究报告了S-OPAT的不良事件数量增加。9项研究共探讨了7种潜在的危险因素，确定了年龄、合并症和金黄色葡萄球菌感染是不良事件的诱因。14项以患者为中心的研究结果表明，患者和护理人员认为S-OPAT是其他OPAT交付模式的合适选择。结论：我们得出结论，S-OPAT是一种可行的护理模式，显示出良好的临床结果，尽管有一些安全问题的报道。当前和未来日益增长的护理需求促使S-OPAT护理进一步发展。知识差距仍然存在，我们为未来的研究提供建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.