Evaluation of survival rate in patients with tongue squamous cell carcinoma: a retrospective single-center study.

IF 2.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Narges Ghazi, Nasrollah Saghravanian, Kazem Anvari, Shadi Saghafi Khadem, Melika Hoseinzadeh, Reza Barzanouni
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Abstract

Background: The tongue squamous cell carcinoma (TSCC) is a highly prevalent form of oral squamous cell carcinoma with poor prognosis and aggressive behavior. The present study aimed to evaluate the association between tumor grade, clinical stage, and survival outcomes in patients with TSCC..

Methodology: Patients with a history of having TSCC, complete clinical and demographic data (age and gender), and a through clinical and histopathological follow-up period of six months were included. The overall survival (OS) and disease-free survival (DFS) of the participants were determined.Histopathological grade was assessed as a secondary objective. Kaplan-Meier survival analysis was performed, and data analysis was conducted using the Kaplan-Meier method, log-rank test and a multivariable Cox regression model.

Results: A total number of 162 patients were included with the mean age of 59.6 ± 15.7 years. The majority of the patients (53.1%) were women. Most patients were classified as Grade I (37.7%) and Stage I (46.3%). The local recurrence and metastasis rates were 12.3% and 4.3%, respectively. The median OS and DFS of the patients included 46 ± 7.8 months and 36 ± 5.7 months, respectively. Five-year OS and DFS rates of 41.5% and 36%. No significant correlation was found between OS and DFS with patients' gender or histological grade. However, OS and DFS were inversely related to the clinical stage and age, showing statistical significance (P < 0.05). Additionally, OS was significantly influenced by tumor size, lymph node involvement, and metastasis (P < 0.05). Factors such as tumor size, lymph node involvement, clinical stage, and patient age significantly impacted OS (P < 0.05). In contrast, lymph node involvement, clinical stage, and patient age were significantly associated with DFS (P < 0.05).

Conclusion: Clinical factors including tumor size, lymph node involvement, clinical stage, and patient age were associated with OS. All these variables were also associated with DFS, except for tumor size. The histopathological grade was not influential on OS or DFS.

舌鳞状细胞癌患者生存率评估:一项回顾性单中心研究。
背景:舌鳞状细胞癌(TSCC)是一种高度流行的口腔鳞状细胞癌,预后差,具有侵袭性。本研究旨在评估TSCC患者的肿瘤分级、临床分期和生存结果之间的关系。方法:纳入有TSCC病史、完整的临床和人口统计学资料(年龄和性别)以及6个月的临床和组织病理学随访期的患者。确定参与者的总生存期(OS)和无病生存期(DFS)。组织病理学分级作为次要目标进行评估。进行Kaplan-Meier生存分析,数据分析采用Kaplan-Meier法、log-rank检验和多变量Cox回归模型。结果:共纳入162例患者,平均年龄59.6±15.7岁。女性占53.1%。大多数患者分为I级(37.7%)和I期(46.3%)。局部复发率12.3%,局部转移率4.3%。患者的中位OS和DFS分别为46±7.8个月和36±5.7个月。5年OS和DFS分别为41.5%和36%。OS和DFS与患者性别或组织学分级无显著相关性。而OS、DFS与临床分期、年龄呈负相关,差异均有统计学意义(P结论:肿瘤大小、淋巴结受累情况、临床分期、患者年龄等临床因素与OS相关。除肿瘤大小外,所有这些变量也与DFS相关。组织病理学分级对OS和DFS均无影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Oral Health
BMC Oral Health DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.90
自引率
6.90%
发文量
481
审稿时长
6-12 weeks
期刊介绍: BMC Oral Health is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the mouth, teeth and gums, as well as related molecular genetics, pathophysiology, and epidemiology.
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