Aptamer-based microfluidics for the detection of cancer biomarkers.

IF 3.8 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Analytical and Bioanalytical Chemistry Pub Date : 2025-07-01 Epub Date: 2025-04-14 DOI:10.1007/s00216-025-05863-7

Yi-Xin-Yue Gong, Xiao-Feng Huang, Jian Liang, Jing Xie, Lin-Sen Qing

引用次数: 0

Abstract

Early diagnosis of cancer is a major concern in clinical medicine. Recently, aptamer-based microfluidics have offered promising platforms for the sensitive detection of cancer biomarkers. This review summarizes the application of aptamer sensors in the microfluidic platform for cancer biomarker analysis. The materials for microfluidic aptamer biosensor fabrication, unique design based on microposts, materials for enhanced detection capability, and the application principle of combining with other detection methods are introduced in detail, so as to demonstrate its development potential in cancer diagnosis and personalized therapy. Finally, the challenges and opportunities for developing miniaturized diagnostic platforms are discussed.

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基于适配体的微流体检测癌症生物标志物。

癌症的早期诊断是临床医学关注的主要问题。近年来，基于适配体的微流体技术为癌症生物标志物的灵敏检测提供了有前景的平台。本文综述了适体传感器在微流控平台癌症生物标志物分析中的应用。详细介绍了微流控适体生物传感器的制备材料、基于微柱的独特设计、增强检测能力的材料以及与其他检测方法相结合的应用原理，以展示其在癌症诊断和个性化治疗方面的发展潜力。最后，讨论了小型化诊断平台发展面临的挑战和机遇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Analytical and Bioanalytical Chemistry 化学-分析化学

CiteScore

8.00

自引率

4.70%

发文量

638

审稿时长

2.1 months

期刊介绍： Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.