Prevalence and factors associated with fatigue in patients with psoriatic arthritis: a systematic review and meta-analysis.

IF 2.1 Q3 RHEUMATOLOGY
Haoming Tang, Tricia Li Ting Chew, Warren Fong
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引用次数: 0

Abstract

Objectives: Fatigue is a prominent symptom in patients with psoriatic arthritis (PsA). There was a wide variety of statistics previously reported on fatigue prevalence in patients. This systematic review examined the current literature to derive the overall prevalence of fatigue and risk factors in PsA patients.

Methods: A systematic review of the literature with subsequent meta-analyses was conducted. Publications assessing fatigue severity and prevalence in patients with PsA using validated measurement scores were identified from seven online databases (Cochrane, CINAHL, EMBASE, Google Scholar, MEDLINE, PubMed, and Web of Science), from inception until January 2024. Employing a random effects model, we calculated the pooled fatigue prevalence. Quality assessment of included studies was performed utilising the Joanna Briggs Critical Appraisal Tool.

Results: The final analysis included 15 studies with 6482 PsA patients. Pooled fatigue prevalence was 0.51 (95% CI: 0.41, 0.61; I2 = 97.4%). There was substantial heterogenicity across the studies, with biologics use and geographical location in terms of Western versus Eastern countries being possible sources of heterogeneity. Age, disease duration, gender, tender joint count, swollen joint and enthesitis count are among the most commonly reported risk factors for fatigue in multivariate logistic regressions.

Conclusions: Approximately half of the patients with PsA experienced fatigue. Biologics use and geographical location of the study were possible sources of heterogeneity in the subgroup analysis.

Clinical trial number: Not applicable.

银屑病关节炎患者疲劳的患病率和相关因素:一项系统回顾和荟萃分析
目的:疲劳是银屑病关节炎(PsA)患者的一个突出症状。有各种各样的统计数据以前报告的疲劳患病率的病人。本系统综述检查了目前的文献,以得出PsA患者疲劳的总体患病率和危险因素。方法:对相关文献进行系统回顾,并进行meta分析。研究人员从7个在线数据库(Cochrane、CINAHL、EMBASE、谷歌Scholar、MEDLINE、PubMed和Web of Science)中确定了从成立到2024年1月,使用验证测量分数评估PsA患者疲劳严重程度和患病率的出版物。采用随机效应模型,计算了混合疲劳流行率。采用Joanna Briggs关键评估工具对纳入的研究进行质量评估。结果:最终分析包括15项研究,6482例PsA患者。合并疲劳患病率为0.51 (95% CI: 0.41, 0.61;i2 = 97.4%)。这些研究存在很大的异质性,西方国家与东方国家的生物制剂使用和地理位置可能是异质性的来源。在多变量logistic回归中,年龄、病程、性别、压痛关节计数、肿胀关节和炎症计数是最常报道的疲劳危险因素。结论:大约一半的PsA患者会出现疲劳。在亚组分析中,生物制剂的使用和研究的地理位置可能是异质性的来源。临床试验号:不适用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Rheumatology
BMC Rheumatology Medicine-Rheumatology
CiteScore
3.80
自引率
0.00%
发文量
73
审稿时长
15 weeks
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