Improvement in Dry Age-Related Macular Degeneration with Photobiomodulation.

IF 0.6 Q4 OPHTHALMOLOGY

Case Reports in Ophthalmology Pub Date : 2025-02-07 eCollection Date: 2025-01-01 DOI:10.1159/000543971

Patrick Xiang Ji, Lauren Pickel, Alan R Berger, Nirojini Sivachandran

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Abstract

Introduction: This case report describes a finding of dramatic improvement in drusen volume and visual acuity in a 73-year-old patient diagnosed with dry age-related macular degeneration (AMD) undergoing daily home photobiomodulation alongside AREDS-2 supplements.

Case presentation: This is a retrospective review of a case presentation from 2023 to 2024. After 8 months of continuous home photobiomodulation, the patient's visual acuity improved from 20/30 to 20/20 in the left eye while the right eye stabilized at 20/25. The outer retina was preserved without signs of geographic atrophy, with a robust reduction in the total number and volume of drusen in both eyes, left greater than right, as shown with optical coherence tomography macular cross-sectional scans.

Conclusions: These findings support that photobiomodulation has the potential to improve the management of dry AMD and the overall quality of life, consistent with phase III clinical trials. Future studies are warranted to further establish optimized protocols for broader clinical implementation.

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光生物调节改善干性老年性黄斑变性。

本病例报告描述了一个73岁的诊断为干性年龄相关性黄斑变性（AMD）的患者，在每日进行家庭光生物调节并补充AREDS-2后，其体积和视力显著改善。病例报告：这是对2023年至2024年的病例报告的回顾性回顾。连续8个月的家庭光生物调节后，患者左眼视力由20/30改善至20/20，右眼视力稳定在20/25。外视网膜保存完好，没有地理萎缩的迹象，双眼的结节总数和体积明显减少，左侧大于右侧，如光学相干断层扫描黄斑横断面扫描所示。结论：这些发现支持光生物调节具有改善干性AMD管理和整体生活质量的潜力，与III期临床试验一致。未来的研究需要进一步建立更广泛的临床应用的优化方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Case Reports in Ophthalmology OPHTHALMOLOGY-

CiteScore

0.90

自引率

0.00%

发文量

129

审稿时长

12 weeks

期刊介绍： This peer-reviewed online-only journal publishes original case reports covering the entire spectrum of ophthalmology, including prevention, diagnosis, treatment, toxicities of therapy, supportive care, quality-of-life, and survivorship issues. The submission of negative results is strongly encouraged. The journal will also accept case reports dealing with the use of novel technologies, both in the arena of diagnosis and treatment. Supplementary material is welcomed. The intent of the journal is to provide clinicians and researchers with a tool to disseminate their personal experiences to a wider public as well as to review interesting cases encountered by colleagues all over the world. Universally used terms can be searched across the entire growing collection of case reports, further facilitating the retrieval of specific information. Following the open access principle, the entire contents can be retrieved at no charge, guaranteeing easy access to this valuable source of anecdotal information at all times.