Long-Term Impact of Intralesional Bony Overgrowth on Opposing Cartilage Integrity: Five-Year Results Following Cartilage Repair.

Abstract

ObjectivesThis study aimed to assess the impact of intralesional bony overgrowth (ILBO) after cartilage repair on the integrity of opposing articulating cartilage (OpAC) using T2 mapping and to correlate these findings with clinical outcomes.MethodsIn this multicenter study, magnetic resonance imaging (MRI) examinations were performed in the follow-up after cartilage repair (Microfracturing (MFX) and Matrix-Induced Autologous Chondrocyte Implantation (MACI)) in 45 patients up to 5 years after surgery. T2 values of the OpAC after 3, 12, and 60 months in patients with and without ILBO after 60 months were conducted along with clinical assessments (International Knee Documentation Committee (IKDC) and Knee injury and Osteoarthritis Outcome Score (KOOS)).ResultsAt 60 months post-surgery, 44.4% of patients presented with ILBO, which was associated with significantly higher T2 values in OpAC (P = 0.004). A tendency toward increased T2 values was observed after 12 months, although this did not reach statistical significance (P = 0.06). However, no significant differences were found in clinical outcomes between patients with or without ILBO, nor between those with or without T2 values comparable to reference cartilage.ConclusionILBO significantly affects the biophysical MRI properties of OpAC as indicated by higher T2 values after 60 months. These alterations, though not reflected in any clinical score, can suggest potential long-term implications for cartilage degeneration and may inform future monitoring strategies for cartilage repair. Further research is required to evaluate the long-term effects of these altered mechanical impacts on articulating cartilage and their clinical implications.