B-ALL with CD34 Negative and Surface Immunoglobulin Light Chain Restricted Expression.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-04-01 DOI:10.7754/Clin.Lab.2024.241018

Simin Chen, Xiaofeng Yang, Yingying Chen, Zhihua Zhang, Xinhong Yang

引用次数: 0

Abstract

Background: The morphologic features of acute lymphoblastic leukemia (ALL) overlap greatly with other blastoid-HGBL or some mature B-cell lymphomas. Blastoid morphology is currently a diagnostic challenge.

Methods and results: Our case presents a B-ALL with surface IgD and immunoglobulin light chain Kappa restricted expression, CD13 and CD33 were partial expressed and negative for CD34. The patient achieved morphologic remission after one cycle of treatment.

Conclusions: In this case, the expression of immunophenotypic features does not clearly distinguish whether the B cells are in a mature or immature stage. In some situations, these lymphoblasts cells are hardly distinguishable from mature cells.

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B-ALL伴CD34阴性和表面免疫球蛋白轻链限制性表达。

背景：急性淋巴细胞白血病（acute lymphoblastic leukemia， ALL）的形态学特征与其他囊胚样细胞- hgbl或某些成熟的b细胞淋巴瘤有很大的重叠。囊胚形态目前是一个诊断挑战。方法和结果：本病例为b型all，表面IgD和免疫球蛋白轻链Kappa受限表达，CD13和CD33部分表达，CD34阴性。经过一个周期的治疗，患者达到了形态学的缓解。结论：本例中，免疫表型特征的表达并不能明确区分B细胞处于成熟期还是未成熟期。在某些情况下，这些淋巴母细胞很难与成熟细胞区分开来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.