Langerhans Cell Histiocytosis of Bone:Report of Eight Cases and Review of the Literature.

Q4 Medicine

中国医学科学院学报 Pub Date : 2025-04-30 DOI:10.3881/j.issn.1000-503X.16077

Ya Bi, Dan-Dan Wu, Fang-Ying Yu, Zhen-Hong Fang, Bo Huang

引用次数: 0

Abstract

Langerhans cell histiocytosis of bone is a rare tumor disease characterized by the large accumulation of CD1a⁺ and CD207⁺ dendritic cells in tissues of unknown cause.It mainly occurs in children aged 1-4 years old,with incidences of 4-6 per million in children and 1-2 per million in adults.Due to its low incidence,diverse clinical manifestations,and no obvious specificity of imaging manifestations,the definitive diagnosis and early treatment of this type of tumor are challenging.In this paper,we report 8 cases of Langerhans cell histiocytosis of bone and review the relevant literature published in the past five years to summarize the clinical characteristics,pathological features,diagnosis,treatment,and prognosis of this disease.

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骨朗格汉斯细胞组织细胞增多症8例报告并文献复习。

骨朗格汉斯细胞组织细胞增多症是一种罕见的肿瘤疾病，其特征是CD1a+和CD207+树突状细胞在组织中大量积聚，原因不明。主要发生在1-4岁的儿童中，儿童发病率为4-6 /百万，成人发病率为1-2 /百万。由于其发病率低，临床表现多样，影像学表现无明显特异性，对其明确诊断和早期治疗具有挑战性。本文报告8例骨朗格汉斯细胞组织细胞增多症，并对近5年来发表的相关文献进行复习，总结本病的临床特点、病理特点、诊断、治疗及预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国医学科学院学报 Medicine-Medicine (all)

CiteScore

0.60

自引率

0.00%

发文量

6813

期刊介绍： Acta Academiae Medicinae Sinicae was founded in February 1979. It is a comprehensive medical academic journal published in China and abroad, supervised by the Ministry of Health of the People's Republic of China and sponsored by the Chinese Academy of Medical Sciences and Peking Union Medical College. The journal mainly reports the latest research results, work progress and dynamics in the fields of basic medicine, clinical medicine, pharmacy, preventive medicine, biomedicine, medical teaching and research, aiming to promote the exchange of medical information and improve the academic level of medicine. At present, the journal has been included in 10 famous foreign retrieval systems and their databases [Medline (PubMed online version), Elsevier, EMBASE, CA, WPRIM, ExtraMED, IC, JST, UPD and EBSCO-ASP]; and has been included in important domestic retrieval systems and databases [China Science Citation Database (Documentation and Information Center of the Chinese Academy of Sciences), China Core Journals Overview (Peking University Library), China Science and Technology Paper Statistical Source Database (China Science and Technology Core Journals) (China Institute of Scientific and Technological Information), China Science and Technology Journal Paper and Citation Database (China Institute of Scientific and Technological Information)].