Selective laser melting fabrication of functionally graded macro-porous Ti-6Al-4V scaffold for cavity bone defect reconstruction.

IF 4.3 3区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1550309
Zhuangzhuang Li, Yi Luo, Ruicheng Liu, Shanfang Zou, Yitian Wang, Taojun Gong, Xuanhong He, Yong Zhou, Minxun Lu, Li Min, Chongqi Tu
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Abstract

Reconstruction of cavitary bone defects poses significant challenges in orthopedic surgery due to the irregular shapes and compromised mechanical properties of surrounding bone. This study developed a functionally graded macro-porous scaffold (FGMPS) using selective laser melting (SLM) for cavitary bone defect reconstruction. The FGMPS featured a porosity gradient (74%-86%) and macropores ≥1,600 µm, mimicking the natural density gradient of cancellous bone. Micro-CT analysis confirmed high structural fidelity and interconnected porosity. Compression tests in two orientations revealed distinct stress-strain responses: vertically aligned gradients (FGMPS-V) exhibited sequential layer engagement, while horizontally aligned gradients (FGMPS-H) demonstrated higher stiffness and strength due to uniform load distribution. The elastic modulus ranged from 383 MPa (FGMPS-V) to 577 MPa (FGMPS-H), with yield strength of 22-40 MPa, aligning well with cancellous bone properties. These findings highlight the FGMPS's potential to offer a promising solution for cavitary bone defect repair.

选择性激光熔融制备功能梯度大孔Ti-6Al-4V骨腔缺损重建支架。
由于周围骨的形状不规则和力学性能受损,腔隙骨缺损的重建在骨科手术中面临着巨大的挑战。本研究利用选择性激光熔化(SLM)技术制备了一种功能梯度大孔支架(FGMPS)用于腔隙骨缺损重建。FGMPS具有孔隙度梯度(74% ~ 86%),大孔≥1600µm,模拟松质骨的自然密度梯度。显微ct分析证实了高结构保真度和互连孔隙度。两个方向的压缩试验显示了不同的应力-应变响应:垂直排列的梯度(FGMPS-V)表现出连续的层接触,而水平排列的梯度(FGMPS-H)由于均匀的载荷分布而表现出更高的刚度和强度。弹性模量为383 MPa (FGMPS-V) ~ 577 MPa (FGMPS-H),屈服强度为22 ~ 40 MPa,符合松质骨的性能。这些发现突出了FGMPS的潜力,为空洞骨缺损修复提供了一个有希望的解决方案。
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来源期刊
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering
CiteScore
8.30
自引率
5.30%
发文量
2270
审稿时长
12 weeks
期刊介绍: The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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