[Clinical outcomes of partial sialoadenectomy for the treatment of benign tumors in the submandibular gland].

Q3 Medicine
北京大学学报(医学版) Pub Date : 2025-04-18
Yuanyuan Yang, Shanshan Zhang, Guangyan Yu, Huijun Yang, Hongyu Yang
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引用次数: 0

Abstract

Objective: To evaluate the clinical outcomes and explore the application of partial sialoadenectomy for the treatment of benign tumors in the submandibular gland (SMG).

Methods: Patients with pleomorphic adenoma of the SMG who underwent surgical treatment in the Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, from October 2017 to February 2021, were enrolled and assessed in the follow-up. Fifteen patients underwent partial sialoadenectomy (PS group), and 18 patients underwent total sialoadenectomy (TS group). Postoperative salivary secretion, degree of dry mouth, appearance changes of the face and neck, nerve damage, and tumor recurrence were compared between the groups. The volume of the glands on the operated and contralateral sides of the patients in the PS group, the saliva flow rate, and their correlations, were also analyzed.

Results: There was no recurrence during the follow-up period. The whole saliva flow rate at rest in the PS group was higher than that in the TS group [(2.15±1.10) g/5 min vs. (1.35±0.97) g/5 min, t=2.208, P=0.035)], while the stimulated saliva flow rate was not significantly different. The objective feeling of dry mouth, evaluated by visual analogue scale (VAS) score, was more obvious in the TS group than in the PS group (Z=-2.244, P=0.025). In the PS group, the resting saliva flow rate of the SMG on the operated side was lower than that on the contralateral side of the same patient [(0.92±0.40) g/5 min vs. (1.18±0.40) g/5 min, t=-2.821, P=0.014], however, in the cases whose remaining SMG was more than 80% of the contralateral side, the saliva flow rate of both sides was not significantly different (t=-0.027, P=0.980). There was no significant difference in the saliva flow rate per unit volume of the gland on either side (t=-0.015, P=0.989), and the saliva flow rate of the operated SMG was positively correlated with the volume of the remaining gland (r=0.750, P=0.012). The VAS scores for neck deformity were not significantly different between the two groups (t=-0.997, P=0.319). No symptoms of nerve injury occurred in either group.

Conclusion: Partial sialoadenectomy in the SMG can safely remove benign tumors while preserving glandular secretory function, with fewer complications and improved quality of life.

[部分涎腺切除术治疗颌下腺良性肿瘤的临床结果]。
目的:评价颌下腺部分涎腺切除术治疗颌下腺良性肿瘤的临床效果,探讨其应用价值。方法:选取2017年10月至2021年2月在北京大学深圳医院口腔颌面外科手术治疗的SMG多形性腺瘤患者,进行随访评估。15例患者行部分涎腺切除术(PS组),18例患者行全涎腺切除术(TS组)。比较两组患者术后唾液分泌、口干程度、面部及颈部外观变化、神经损伤及肿瘤复发情况。分析PS组患者手术侧和对侧腺体体积、唾液流速及其相关性。结果:随访期间无复发。PS组静止时全唾液流率高于TS组[(2.15±1.10)g/5 min vs(1.35±0.97)g/5 min, t=2.208, P=0.035],而刺激唾液流率差异无统计学意义。用视觉模拟评分法(VAS)评价TS组的口干客观感觉明显优于PS组(Z=-2.244, P=0.025)。PS组手术侧SMG的静息唾液流率低于同一患者对侧SMG的静息唾液流率[(0.92±0.40)g/5 min vs(1.18±0.40)g/5 min, t=-2.821, P=0.014],而在SMG剩余量大于对侧80%的病例中,双方唾液流率无显著差异(t=-0.027, P=0.980)。两侧腺体单位体积唾液流率差异无统计学意义(t=-0.015, P=0.989),手术SMG的唾液流率与剩余腺体体积呈正相关(r=0.750, P=0.012)。两组患者颈部畸形VAS评分差异无统计学意义(t=-0.997, P=0.319)。两组均未出现神经损伤症状。结论:SMG部分涎腺切除术可在保留腺体分泌功能的同时安全切除良性肿瘤,并发症少,生活质量提高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
北京大学学报(医学版)
北京大学学报(医学版) Medicine-Medicine (all)
CiteScore
0.80
自引率
0.00%
发文量
9815
期刊介绍: Beijing Da Xue Xue Bao Yi Xue Ban / Journal of Peking University (Health Sciences), established in 1959, is a national academic journal sponsored by Peking University, and its former name is Journal of Beijing Medical University. The coverage of the Journal includes basic medical sciences, clinical medicine, oral medicine, surgery, public health and epidemiology, pharmacology and pharmacy. Over the last few years, the Journal has published articles and reports covering major topics in the different special issues (e.g. research on disease genome, theory of drug withdrawal, mechanism and prevention of cardiovascular and cerebrovascular diseases, stomatology, orthopaedic, public health, urology and reproductive medicine). All the topics involve latest advances in medical sciences, hot topics in specific specialties, and prevention and treatment of major diseases. The Journal has been indexed and abstracted by PubMed Central (PMC), MEDLINE/PubMed, EBSCO, Embase, Scopus, Chemical Abstracts (CA), Western Pacific Region Index Medicus (WPR), JSTChina, and almost all the Chinese sciences and technical index systems, including Chinese Science and Technology Paper Citation Database (CSTPCD), Chinese Science Citation Database (CSCD), China BioMedical Bibliographic Database (CBM), CMCI, Chinese Biological Abstracts, China National Academic Magazine Data-Base (CNKI), Wanfang Data (ChinaInfo), etc.
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