Gluten and its relationship with inflammation and Parkinson's Disease: A literature review.

IF 3.1 Q2 NEUROSCIENCES

AIMS Neuroscience Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI:10.3934/Neuroscience.2025004

Zohaer Muttalib, Dana Aboukhalil, Chisom Nwosu, Dave D Manguerra, Jimmy Wen, Ubaid Ansari, Meraj Alam, Ihab Abed, Ethan Tabaie, Ahmed Salem, Forshing Lui

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引用次数: 0

Abstract

Parkinson's Disease is a neurodegenerative central nervous system (CNS) disease that primarily affects the dopaminergic cells of the Substantia Nigra in the midbrain and causes a diverse array of symptoms, including dystonia, a loss of balance, difficulty initiating movements, akinesia, muscle spasms, and tremors. It has long been known that environmental and commercial compounds are linked to an increased risk of Parkinson's Disease. Of importance, gluten, a complex polysaccharide, has been hypothesized to cause some of the symptoms related to Parkinson's Disease. It is hypothesized that gluten causes a chronic inflammatory state which may lead to plaque formation and neuronal cell death in the substantia nigra, alongside the symptoms of Parkinson's Disease. This literature review hopes to explore the relationship gluten has as an inflammatory molecule and its role in the production and prolongation of the disease processes in Parkinson's Disease.

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麸质及其与炎症和帕金森病的关系：文献综述。

帕金森病是一种神经退行性中枢神经系统（CNS）疾病，主要影响中脑黑质的多巴胺能细胞，并引起多种症状，包括肌张力障碍、平衡丧失、启动运动困难、运动障碍、肌肉痉挛和震颤。人们早就知道，环境和商业化合物与帕金森病风险增加有关。重要的是，谷蛋白，一种复杂的多糖，已经被假设会引起一些与帕金森病相关的症状。据推测，谷蛋白引起慢性炎症状态，可能导致黑质斑块形成和神经元细胞死亡，以及帕金森病的症状。本文献综述希望探讨谷蛋白作为炎症分子在帕金森病发病和病程延长中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIMS Neuroscience NEUROSCIENCES-

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers from all areas in the field of neuroscience. The primary focus is to provide a forum in which to expedite the speed with which theoretical neuroscience progresses toward generating testable hypotheses. In the presence of current and developing technology that offers unprecedented access to functions of the nervous system at all levels, the journal is designed to serve the role of providing the widest variety of the best theoretical views leading to suggested studies. Single blind peer review is provided for all articles and commentaries.