Evaluation of annexin A1, carbonic anhydrase 1, and elongation factor 1-gamma levels in periodontal diseases.

IF 2.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

BMC Oral Health Pub Date : 2025-05-02 DOI:10.1186/s12903-025-06049-4

Bilge Cansu Uzun Saylan, Büşra Yılmaz, Veli Özgen Öztürk, Harika Atmaca, Gülnur Emingil

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引用次数: 0

Abstract

Background: Periodontitis arises from dysbiotic subgingival microbiota and an unresolved inflammatory response. Annexin A1 (ANXA1), Carbonic Anhydrase I (CA1), and Elongation Factor 1-gamma (EF1-Ɣ) may play a role in periodontal inflammation and disease pathogenesis. This study aimed to investigate the levels of these molecules in gingival crevicular fluid (GCF) of individuals with different periodontal conditions.

Methods: GCF samples were collected from 20 patients with Stage III Grade B periodontitis, 20 with Stage III Grade C periodontitis, 19 gingivitis patients, and 21 periodontally healthy individuals. ANXA1, CA1, and EF1-Ɣ levels were measured using ELISA.

Results: Clinical parameters were significantly higher in periodontitis groups compared to gingivitis and healthy groups (p < 0.001). GCF EF1-Ɣ total amount differed among groups, with higher levels in gingivitis compared to periodontitis and healthy control groups (p < 0.001). Elevated levels of EF1-Ɣ were found in gingivitis compared to Stage III/B and Stage III/C periodontitis (p < 0.001). GCF ANXA1 and CA1 levels were similar across study groups (p > 0.05).

Conclusion: Within the limitations of this study, it might be suggested that the decreased levels of EF1-Ɣ in diseased sites of periodontitis and its elevated levels in gingivitis are associated with the pathogenesis of periodontal disease.

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牙周病患者膜联蛋白A1、碳酸酐酶1和延伸因子1- γ水平的评估

背景：牙周炎起源于牙龈下菌群失调和未解决的炎症反应。膜联蛋白A1 （ANXA1）、碳酸酐酶I （CA1）和延伸因子1- γ （EF1-Ɣ）可能在牙周炎症和疾病发病机制中发挥作用。本研究旨在探讨不同牙周疾病个体龈沟液（GCF）中这些分子的水平。方法：收集20例III期B级牙周炎患者、20例III期C级牙周炎患者、19例牙龈炎患者和21例牙周健康者的GCF样本。ELISA法检测ANXA1、CA1、EF1-Ɣ水平。结果：牙周炎组临床指标明显高于牙龈炎组和健康组（p < 0.05）。结论：在本研究的局限性内，可能提示牙周炎发病部位EF1-Ɣ水平的降低和牙龈炎部位EF1-Ɣ水平的升高与牙周病的发病机制有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Oral Health DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

6.90%

发文量

481

审稿时长

6-12 weeks

期刊介绍： BMC Oral Health is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the mouth, teeth and gums, as well as related molecular genetics, pathophysiology, and epidemiology.