Effect of Del Nido Cardioplegia Versus Plegisol Solution on Myocardial Protection in Cardiopulmonary Bypass.

IF 0.9 4区医学 Q3 SURGERY

Annali italiani di chirurgia Pub Date : 2025-01-01 DOI:10.62713/aic.3817

Bişar Amaç, Ertuğrul Ertuğrul, Mustafa Abanoz, Mesut Engin

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引用次数: 0

Abstract

Aim: This study aimed to compare the efficacy of the routinely used modified del Nido cardioplegia and Plegisol® solution in myocardial protection.

Methods: In this retrospective study, patients who underwent cardiopulmonary bypass (CPB) guided cardiac surgery and received del Nido cardioplegia solution (Group 1) and Plegisol® solution (Group 2) were compared in terms of early clinical data and myocardial protection.

Results: This study included 68 patients with similar demographic characteristics who received 38 modified del Nido cardioplegia and 30 Plegisol® solutions. Creatine kinase-myocardial bound (CK-MB) and cardiac troponin T (CTnT) levels on postoperative day 1 and CTnT levels on postoperative day 5 were higher in Group 2 and there was a significant difference between the groups (p = 0.025, p = 0.001, p = 0.001, respectively). In addition, the postoperative inotrope requirement and postoperative vasoactive-inotropic score were higher in Group 2 and there was a significant difference between the two groups (p = 0.004, p = 0.002, respectively).

Conclusions: In this study, the del Nido cardioplegia solution was found to be more advantageous regarding the need for intracardiac defibrillation and myocardial necrosis, although it showed similar results in some points when compared with the Plegisol® solution.

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德尔尼多停搏液对体外循环心肌保护的影响。

目的：本研究旨在比较常规使用的改良del Nido心脏停搏液和Plegisol®溶液对心肌的保护作用。方法：回顾性分析在体外循环（CPB）引导下接受心脏手术并接受del Nido停搏液（1组）和Plegisol®停搏液（2组）患者的早期临床资料和心肌保护效果。结果：本研究纳入了68例具有相似人口统计学特征的患者，他们接受了38例改良del Nido心脏停搏液和30例Plegisol®解决方案。术后第1天肌酸激酶-心肌结合酶（CK-MB）和第5天心肌肌钙蛋白T （CTnT）水平在第2组较高，组间比较差异有统计学意义（p = 0.025, p = 0.001, p = 0.001）。此外，组2术后肌力需要量和术后血管活性肌力评分较高，两组间差异有统计学意义（p = 0.004, p = 0.002）。结论：在本研究中，尽管与Plegisol®溶液相比，del Nido心脏骤停溶液在需要心内除颤和心肌坏死方面更有优势，但在某些方面显示出相似的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annali italiani di chirurgia 医学-外科

CiteScore

0.90

自引率

12.50%

发文量

116

审稿时长

>12 weeks

期刊介绍： Annali Italiani di Chirurgia is a bimonthly journal and covers all aspects of surgery:elective, emergency and experimental surgery, as well as problems involving technology, teaching, organization and forensic medicine. The articles are published in Italian or English, though English is preferred because it facilitates the international diffusion of the journal (v.Guidelines for Authors and Norme per gli Autori). The articles published are divided into three main sections:editorials, original articles, and case reports and innovations.