The effect of exercise therapy on pain, fatigue, bone function and inflammatory biomarkers individuals with rheumatoid arthritis and knee osteoarthritis: a meta-research review of randomized controlled trials.

IF 3.2 3区医学 Q2 PHYSIOLOGY

Frontiers in Physiology Pub Date : 2025-04-09 eCollection Date: 2025-01-01 DOI:10.3389/fphys.2025.1558214

Xiaoting Fu, Liang Zhang, Cuijuan Wang, Jun Yue, Hang Zhu

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Abstract

Background: Accumulating evidence suggested the potential role of exercise in alleviating rheumatoid arthritis (RA). However, whether exercise improves physical function (walk test, grip strength, muscle strength, joint assessments) and inflammatory biomarkers in patients with RA is unclear. This umbrella meta-analysis aimed to examine the effect of exercise in patients with RA.

Method: PubMed, Scopus, Web of Science, Embase, and Cochrane Central Library databases were systematically searched for meta-analyses of randomized control trials (RCTs) to retrieve relevant studies. The effect sizes were pooled using a random-effects model, with standardized or weighted mean differences (SMDs or WMDs) and 95% confidence intervals (CIs) as summary statistics.

Results: Seventeen studies were included. The improving effects of exercise on fatigue levels (SMD = -0.28, 95% CI: -0.44, -0.13), pain intensity (ES = -0.50, 95% CI: -0.87, -0.14), disease activity score in joints (DAS) (WMD = -0.54, 95% CI: -0.99, -0.09; and SMD = -0.47, 95% CI: -0.64, -0.30), and ESR (ES = -0.85, 95% CI: -1.66, -0.03) were significant. No significant impact on the hand grip, muscle strength, walk test, joints and inflammatory biomarkers was observed.

Conclusion: Exercise significantly reduces fatigue, pain, DAS, and ESR in RA but shows no impact on grip strength, muscle strength, walk test, joints, or other inflammatory biomarkers. This highlights its role in symptom management rather than broad physiological changes.

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运动疗法对类风湿关节炎和膝骨关节炎患者疼痛、疲劳、骨功能和炎症生物标志物的影响：随机对照试验的荟萃研究综述。

背景：越来越多的证据表明运动在缓解类风湿性关节炎（RA）中的潜在作用。然而，运动是否能改善RA患者的身体功能（步行测试、握力、肌肉力量、关节评估）和炎症生物标志物尚不清楚。这项综合荟萃分析旨在研究运动对类风湿性关节炎患者的影响。方法：系统检索PubMed、Scopus、Web of Science、Embase和Cochrane中央图书馆数据库，检索随机对照试验（RCTs）的meta分析，检索相关研究。使用随机效应模型汇总效应量，采用标准化或加权平均差异（SMDs或wmd）和95%置信区间（ci）作为汇总统计量。结果：纳入17项研究。运动对疲劳水平（SMD = -0.28, 95% CI: -0.44, -0.13）、疼痛强度（ES = -0.50, 95% CI: -0.87, -0.14）、关节疾病活动评分（DAS） (WMD = -0.54, 95% CI: -0.99, -0.09；SMD = -0.47, 95% CI: -0.64, -0.30), ESR （ES = -0.85, 95% CI: -1.66, -0.03）具有统计学意义。对握力、肌肉力量、步行测试、关节和炎症生物标志物没有显著影响。结论：运动可显著减轻RA患者的疲劳、疼痛、DAS和ESR，但对握力、肌肉力量、步行测试、关节或其他炎症生物标志物没有影响。这突出了它在症状管理中的作用，而不是广泛的生理变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Physiology PHYSIOLOGY-

CiteScore

6.50

自引率

5.00%

发文量

2608

审稿时长

14 weeks

期刊介绍： Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.