Preconceptional treatment with açaí juçara (Euterpe edulis Martius) in advanced-age female rats did not interfere with metabolic parameters and redox balance during pregnancy.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2025-05-08 DOI:10.1080/13813455.2025.2497260

Mayra Dias Rodrigues, Brenda Francisconi Diaz, Fernando Henrique Borges, Rhauany Pelisson Guergolette, Larissa Rugila Dos Santos Stopa, Ernane Torres Uchoa, Glaura Scantamburlo Alves Fernandes, Karla Bigetti Guergoletto, Graziela Scalianti Ceravolo

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Abstract

The consumption of açaí has been shown to be beneficial to health. This study aimed to evaluate the effects of juçara açai (JU, Euterpe edulis Martius) administration before gestation on the biometric, metabolic, and oxidative status in pregnant rats of advanced maternal age. Healthy female Wistar rats were treated with JU pulp via gavage from postnatal day 168 to 210. After treatment, the rats were mated, and during the 20 days of pregnancy, they were evaluated for body weight (BW), glucose tolerance, adipose tissue and liver weight, the lipid profile, and hepatic oxidative status. At birth, the offspring were weighed and counted. It was observed that JU reduced just maternal glycaemia. The maternal preconceptional treatment did not affect offspring BW. These results suggest that JU could be a safe nutritional intervention during the preconception period in advanced maternal age.

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对高龄雌性大鼠进行açaí juara （Euterpe edulis Martius）孕前处理不会干扰妊娠期间的代谢参数和氧化还原平衡。

食用açaí已被证明对健康有益。本研究旨在评估妊娠前给药juara aai （JU, Euterpe edulis Martius）对高龄妊娠大鼠生物特征、代谢和氧化状态的影响。健康雌性Wistar大鼠从出生后第168天至第210天灌胃JU髓。给药后，对大鼠进行交配，并在妊娠20天内对大鼠的体重、葡萄糖耐量、脂肪组织和肝脏重量、脂质谱和肝脏氧化状态进行评估。在出生时，对后代进行称重和计数。观察到JU仅降低母体血糖。母体孕前处理对子代体重无影响。这些结果表明，JU可能是一种安全的营养干预在孕前的高龄产妇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.