Real-life and in vitro evaluation of the antimicrobial effectiveness of a polycationic fabric coating.

IF 3.8 3区医学 Q2 INFECTIOUS DISEASES

American journal of infection control Pub Date : 2025-04-09 DOI:10.1016/j.ajic.2025.04.001

Alejandro Gómez-Mejia, Jessica Franz, Mirjam Faes Hesse, Ashlesha Sonpar, Mahsa Zabara, Stefan Salentinig, Jules D P Valentin, Annelies S Zinkernagel, Silvio D Brugger, Aline Wolfensberger

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引用次数: 0

Abstract

Background: Inanimate surfaces, including hospital textiles, are increasingly recognized to play a role in pathogen transmission. We aimed to evaluate a polycationic antimicrobial fabric coating in reducing bacterial burden in vitro and in hospital settings.

Methods: Cotton fabric patches (coated and uncoated) were exposed to bacterial contamination: (1) in vitro, by dry contamination with Staphylococcus aureus or Escherichia coli, and (2) in clinical settings. Recovery was performed by 2 methods: Swabbing (method 1) and sonicating (method 2). Colony forming units (CFU) per paired coated and uncoated fabric patch were compared.

Results: From the field tests, 48 pairs of fabric patches were analyzed. With method 1, the median bacterial CFU per fabric patch was 16 CFU on uncoated fabric and 39 CFU on coated fabric. With method 2, the median bacterial CFU per fabric patch was 132 CFU on uncoated fabric, and 0 CFU on coated fabric. In vitro assessment with 24 paired patches confirmed these findings.

Conclusions: Polymer-coated fabric effectively lowered bacterial burden when recovery was performed by liquid extraction, while effectiveness could not be demonstrated when bacteria were recovered with swabs. Further investigations are required to explore potential implications for effectiveness evaluation in clinical settings.

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聚阳离子织物涂层的实际和体外抗菌效果评价。

背景：无生命的表面，包括医院的纺织品，越来越被认为在病原体传播中起作用。我们的目的是评估多阳离子抗菌织物涂层在体外和医院环境中减少细菌负担。方法：棉织物贴片（涂覆和未涂覆）暴露于细菌污染：(1)在体外，用金黄色葡萄球菌或大肠杆菌干污染；(2)在临床环境中。采用拭子法（方法1）和超声法（方法2）进行回收。每对涂覆和未涂覆织物斑块的菌落形成单位（CFU）进行了比较。结果：从现场试验中，分析了48对织物贴片。方法1每个织物贴片细菌CFU的中位数在未涂覆织物上为16 CFU，在涂覆织物上为39 CFU。方法2每个织物贴片细菌CFU的中位数在未涂覆织物上为132 CFU，在涂覆织物上为0 CFU。24个配对贴片的体外评估证实了这些发现。结论：聚合物包被织物可有效降低液体萃取法回收细菌的负荷，而棉签法回收细菌的效果不明显。需要进一步的研究来探索临床环境中有效性评估的潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of infection control 医学-传染病学

CiteScore

7.40

自引率

4.10%

发文量

479

审稿时长

24 days

期刊介绍： AJIC covers key topics and issues in infection control and epidemiology. Infection control professionals, including physicians, nurses, and epidemiologists, rely on AJIC for peer-reviewed articles covering clinical topics as well as original research. As the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC)