Multidrug-Resistant Escherichia coli Isolated from Stool Samples of Healthy Infants in Rural Bangladeshi Communities.

IF 1.9 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-05-13 DOI:10.4269/ajtmh.24-0541

Fatema-Tuz Johura, Jarin Tasnim, Sahitya Ranjan Biswas, Riajul Islam, Talal Hossain, Hafizur Rahman, Saijuddin Shaikh, Hasmot Ali, Subhra Chakraborty, Alain Labrique, Tahmeed Ahmed, Md Iqbal Hossain, Munirul Alam, Amanda C Palmer

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Abstract

Escherichia coli (E. coli) is a commensal organism in humans and animals. It can serve as a reservoir for antibiotic resistance, thus providing an indicator of drug resistance patterns in a community. We investigated antibiotic resistance in E. coli isolated from nondiarrheal stool samples of 6-month-old infants (n = 110) from northwest Bangladesh. We conducted susceptibility testing using a disc diffusion assay against 20 antibiotics. Resistance was most pronounced for macrolides (98.2% resistant), whereas the most sensitive antibiotics were fosfomycin (100%), gentamicin (99.1%), meropenem (98.2%), mecillinam (97.3%), tigecycline (97.3%), and imipenem (87.3%). Excluding erythromycin, roughly 55% of isolates were multidrug-resistant. Our results likely reflect the burden of drug-resistant E. coli in the guts of infants in rural Bangladesh and the prevailing drug resistance patterns in this community.

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从孟加拉国农村社区健康婴儿粪便样本中分离出耐多药大肠杆菌

大肠杆菌是人类和动物的一种共生生物。它可以作为抗生素耐药性的储存库，从而提供一个社区耐药模式的指标。我们调查了从孟加拉国西北部6个月大婴儿（n = 110）的非腹泻性粪便样本中分离的大肠杆菌的抗生素耐药性。采用圆盘扩散法对20种抗生素进行药敏试验。大环内酯类抗生素耐药率最高（98.2%），而最敏感的抗生素为磷霉素（100%）、庆大霉素（99.1%）、美罗培南（98.2%）、美西林南（97.3%）、替加环素（97.3%）和亚胺培南（87.3%）。除红霉素外，约55%的分离株具有多重耐药性。我们的结果可能反映了孟加拉国农村婴儿肠道中耐药大肠杆菌的负担以及该社区普遍存在的耐药模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.20

自引率

3.00%

发文量

508

审稿时长

3 months

期刊介绍： The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is among the top-ranked tropical medicine journals in the world publishing original scientific articles and the latest science covering new research with an emphasis on population, clinical and laboratory science and the application of technology in the fields of tropical medicine, parasitology, immunology, infectious diseases, epidemiology, basic and molecular biology, virology and international medicine. The Journal publishes unsolicited peer-reviewed manuscripts, review articles, short reports, images in Clinical Tropical Medicine, case studies, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies,new testing methods and equipment, book reports and Letters to the Editor. Topics range from applied epidemiology in such relevant areas as AIDS to the molecular biology of vaccine development. The Journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists and public health officials who are concerned with health issues of the tropics, developing nations and emerging infectious diseases. Major granting institutions including philanthropic and governmental institutions active in the public health field, and medical and scientific libraries throughout the world purchase the Journal. Two or more supplements to the Journal on topics of special interest are published annually. These supplements represent comprehensive and multidisciplinary discussions of issues of concern to tropical disease specialists and health issues of developing countries