I Yu Burovenko, Yu Yu Borshchev, S M Minasyan, E S Protsak, O V Borshcheva, M M Galagudza
{"title":"Brain-Derived Neurotrophic Factor Cancels the Cardioprotective Effect of Interleukin-2 in a Model of Systemic Inflammatory Response in Rats.","authors":"I Yu Burovenko, Yu Yu Borshchev, S M Minasyan, E S Protsak, O V Borshcheva, M M Galagudza","doi":"10.1007/s10517-025-06377-z","DOIUrl":null,"url":null,"abstract":"<p><p>Contradictory data about the cardioprotective and neuroprotective effects of IL-2 and BDNF and our own data on specific differences in myocardial resistance to ischemia-reperfusion after administration of exogenous IL-2 and BDNF prompted us to study the effect of combined administration of these two agents on the size of the necrosis zone in the isolated heart of rats with modeled systemic inflammatory response syndrome (SIRS). In the SIRS group, a significant increase in most proinflammatory markers in the blood and a 65% increase in the area of myocardial necrosis after ischemia-reperfusion in comparison with the control were observed. After IL-2 administration, the necrosis zone was significantly smaller than in rats with SIRS and the level of most analytes decreased. Combined administration of IL-2 and BDNF abolished the decrease in the size of the necrosis zone compared to that in rats with SIRS.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 5","pages":"577-580"},"PeriodicalIF":0.9000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06377-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/29 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Contradictory data about the cardioprotective and neuroprotective effects of IL-2 and BDNF and our own data on specific differences in myocardial resistance to ischemia-reperfusion after administration of exogenous IL-2 and BDNF prompted us to study the effect of combined administration of these two agents on the size of the necrosis zone in the isolated heart of rats with modeled systemic inflammatory response syndrome (SIRS). In the SIRS group, a significant increase in most proinflammatory markers in the blood and a 65% increase in the area of myocardial necrosis after ischemia-reperfusion in comparison with the control were observed. After IL-2 administration, the necrosis zone was significantly smaller than in rats with SIRS and the level of most analytes decreased. Combined administration of IL-2 and BDNF abolished the decrease in the size of the necrosis zone compared to that in rats with SIRS.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
