Rare Case of Tacrolimus-Induced Acute Pancreatitis in a Liver Transplant Recipient.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2025-04-25 eCollection Date: 2025-05-01 DOI:10.14309/crj.0000000000001659

Renan Prado, Arjun Chatterjee, Zurabi Zaalishvili, Rupayan Kundu, Shilpa Junna, Shreya Sengupta, Nizar Zein, Syed A Mohiuddin

引用次数: 0

Abstract

Tacrolimus-induced acute pancreatitis (TAP) is rare and requires thorough evaluation, including genetic testing, to rule out other causes. While TAP has been documented in a few cases following kidney transplantation, we report the first case of TAP in an adult after liver transplantation, with a noteworthy feature of late-onset TAP occurring more than 12 months after initiating tacrolimus therapy. This case highlights the potential for delayed onset of TAP, and we suggest that tacrolimus may warrant reclassification from category III to Ic in the drug-induced pancreatitis classification. In addition, we introduce sirolimus as a viable alternative for immunosuppression following TAP.

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他克莫司致肝移植受者急性胰腺炎的罕见病例。

他克莫司诱发的急性胰腺炎（TAP）是罕见的，需要彻底的评估，包括基因检测，以排除其他原因。虽然在肾移植后的少数病例中有TAP的记录，但我们报告了首例肝移植后成人TAP病例，其值得注意的特征是在开始他克莫司治疗后超过12个月发生迟发性TAP。该病例突出了TAP延迟发作的可能性，我们建议他克莫司在药物性胰腺炎分类中可能需要从III类重新分类到Ic类。此外，我们引入西罗莫司作为TAP后免疫抑制的可行替代方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.