Effectiveness of dolutegravir-based treatment among HIV/AIDS patients in Nkembo Outpatient Treatment Center, Gabon.

IF 2.1 4区 医学 Q3 INFECTIOUS DISEASES
Christian Mangala, Rolf Moukanda-Ifoundou, Denis Maulot-Bangola, Alain Moutsinga, Christian Mombo-Maganga, Serge Christian Okolongo-Mayani, Brice Ongali, Guy Joseph Lemamy, Rachyda Massolou-Outata
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Abstract

Background: HIV/AIDS therapy continues to make an enormous contribution to improving the well-being of HIV/AIDS patients globally. In Gabon, dolutegravir is administered to HIV/AIDS patients from first-line treatment. This study aimed to determine the effectiveness rate of dolutegravir-based treatment among HIV/AIDS patients.

Methods: A retrospective observational study was conducted among HIV/AIDS patients who started antiretroviral treatment since 48 weeks of follow-up.

Results: The effectiveness rate of dolutegravir-based treatment was 85.1%. HIV/AIDS patients with a CD4 + count below 200 cel/mm3, singles, and HIV/AIDS patients whose treatment duration exceeded 12 months were at risk and likely to have an active infection (P = 0.0001).

Conclusion: Dolutegravir-based treatment remains effective among HIV/AIDS patients treated at the Nkembo Outpatient Treatment Center.

加蓬恩肯博门诊治疗中心对艾滋病毒/艾滋病患者的多替替韦治疗效果
背景:艾滋病毒/艾滋病治疗继续为改善全球艾滋病毒/艾滋病患者的福祉作出巨大贡献。在加蓬,从一线治疗开始,就给艾滋病毒/艾滋病患者使用多替格拉韦。本研究旨在确定多替地韦治疗HIV/AIDS患者的有效性。方法:对开始抗逆转录病毒治疗的HIV/AIDS患者进行回顾性观察性研究,随访48周。结果:以盐酸地维韦为主的治疗有效率为85.1%。CD4 +计数低于200细胞/mm3的HIV/AIDS患者和治疗持续时间超过12个月的HIV/AIDS患者存在风险,并且可能存在活动性感染(P = 0.0001)。结论:在恩肯博门诊治疗中心接受治疗的艾滋病毒/艾滋病患者中,以多路替格雷韦为基础的治疗仍然有效。
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来源期刊
AIDS Research and Therapy
AIDS Research and Therapy INFECTIOUS DISEASES-
CiteScore
3.80
自引率
4.50%
发文量
51
审稿时长
16 weeks
期刊介绍: AIDS Research and Therapy publishes articles on basic science, translational, clinical, social, epidemiological, behavioral and educational sciences articles focused on the treatment and prevention of HIV/AIDS, and the search for the cure. The Journal publishes articles on novel and developing treatment strategies for AIDS as well as on the outcomes of established treatment strategies. Original research articles on animal models that form an essential part of the AIDS treatment research are also considered
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