Two-dimensional Co-based metal-organic framework nanosheets as an efficient electrochemical sensing platform for simultaneous determination of daunorubicin and idarubicin.

Abstract

Background and purpose: Chemotherapy is the most effective and commonly utilized cancer treatment method. Therefore, studies on the sensitive determination of chemotherapy drugs used in cancer treatment can be very effective in improving treatment and reducing their side effects.

Experimental approach: The two-dimensional Co-based metal-organic framework nanosheets (2D Co-MOF NSs) were synthesized and then utilized to modify the screen-printed carbon electrode (2D Co-MOF NSs/SPCE). The 2D Co-MOF NSs/SPCE was successfully used for the determination of daunorubicin (DNR). Furthermore, we utilized differential pulse voltammetry, cyclic voltammetry, and chronoamperometry to evaluate the electrochemical properties of the created electrode.

Key results: The obtained results from CV studies demonstrate that this sensor exhibits outstanding electrocatalytic activity for the redox process of DNR. Under optimal experimental conditions, quantitative measurements resulted in a linear concentration range from 0.004 to 450.0 μM for DNR with a limit of detection (LOD) of 0.001 μM. Furthermore, the fabricated electrode was used for the simultaneous voltammetric detection of DNR and idarubicin (IDR). According to the results, the 2D Co-MOF NSs/SPCE sensor showed two well-defined peaks for the voltammetric oxidation of DNR and IDR. Eventually, the practical sample detection of DNR and IDR was successfully validated with acceptable results.

Conclusion: The developed sensing platform will be beneficial for enabling effective medical strategies to improve the clinical efficacy of chemotherapy drugs.