A new method for measuring dopamine in the presence of uric acid employing a carbon paste electrode modified with the UiO-66 metal organic framework-graphene oxide nanocomposite.

IF 3.4 Q2 CHEMISTRY, MEDICINAL

ADMET and DMPK Pub Date : 2025-02-04 eCollection Date: 2025-01-01 DOI:10.5599/admet.2593

Azhar Hameed Gatea, Aseer Shakir Ajel, Raed Muslim Mhaibes

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引用次数: 0

Abstract

Background and purpose: Dopamine has an impact on the cardiovascular, endocrine, renal, and central neurological systems. Electrochemical techniques are becoming more and more popular among researchers as a way to assess dopamine and uric acid levels.

Experimental approach: Using electrochemical techniques, a new Universitet i Oslo MOF (UiO-66)-graphene oxide nanocomposite-modified carbon paste electrode was created to investigate the electrooxidation of uric acid and dopamine as well as their combinations. At the redesigned electrode, uric acid and dopamine were detected concurrently in a very sensitive way using differential pulse voltammetry (DPV).

Key results: Dopamine DPV peak currents increase in a linear fashion at doses between 0.05 and 600.0 μM.

Conclusion: Uric acid and dopamine levels in urine and dopamine injection samples may be determined with the help of the proposed sensor, which is reasonably priced and performs well.

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采用UiO-66金属有机骨架-氧化石墨烯纳米复合材料修饰的碳糊电极，研究了一种在尿酸存在下测量多巴胺的新方法。

背景和目的：多巴胺对心血管、内分泌、肾脏和中枢神经系统有影响。电化学技术作为一种评估多巴胺和尿酸水平的方法越来越受到研究人员的欢迎。实验方法：利用电化学技术，创造了一种新的奥斯陆大学MOF (UiO-66)-氧化石墨烯纳米复合材料修饰的碳糊电极，用于研究尿酸和多巴胺的电氧化及其组合。在重新设计的电极上，使用差分脉冲伏安法（DPV）以非常敏感的方式同时检测尿酸和多巴胺。主要结果：在0.05 ~ 600.0 μM剂量范围内，多巴胺DPV峰电流呈线性增加。结论：该传感器价格合理，性能良好，可用于尿液和多巴胺注射样品中的尿酸和多巴胺水平的检测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ADMET and DMPK Multiple-

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： ADMET and DMPK is an open access journal devoted to the rapid dissemination of new and original scientific results in all areas of absorption, distribution, metabolism, excretion, toxicology and pharmacokinetics of drugs. ADMET and DMPK publishes the following types of contributions: - Original research papers - Feature articles - Review articles - Short communications and Notes - Letters to Editors - Book reviews The scope of the Journal involves, but is not limited to, the following areas: - physico-chemical properties of drugs and methods of their determination - drug permeabilities - drug absorption - drug-drug, drug-protein, drug-membrane and drug-DNA interactions - chemical stability and degradations of drugs - instrumental methods in ADMET - drug metablic processes - routes of administration and excretion of drug - pharmacokinetic/pharmacodynamic study - quantitative structure activity/property relationship - ADME/PK modelling - Toxicology screening - Transporter identification and study