Three-dimensional AuNRs/MXene/NFs -based SERS platform for determination of quetiapine in urine.

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2025-10-01 Epub Date: 2025-04-14 DOI:10.1016/j.talanta.2025.128157

Jiamin Gong, Boran Zhang, Qinyi Li, Jiangli Shi, Xinling Liu, Yiping Wu, Ying Wen, Xiaoyu Guo, Haifeng Yang

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引用次数: 0

Abstract

Determination of antipsychotic drugs in humans is meaningful for both individualized therapy and therapeutic drug monitoring. Quetiapine (QTP), as one of the newly developed antipsychotic drugs, may pose risks to human health if used improperly. In this work, we synthesized a three-dimensional (3D) Au nanorods/MXene (Ti₃C₂T_x)/nickel foams (named as AuNRs/MXene/NFs) composite material for detecting the antipsychotic drugs QTP. The prepared negatively charged MXene was first assembled on the surface of the NFs through electrostatic interaction to form MXene/NFs, and then the prepared AuNRs were anchored on the MXene/NFs to obtain the final 3D AuNRs/MXene/NFs. By integrating the porous structure and magnetic properties of NFs, large specific surface area of MXene, and the plasmonic hot spots of Au nanorods, the AuNRs/MXene/NFs-based SERS platform can easily and sensitively detect QTP in human urine with the limit of detection of 1.71 × 10^-9 mol/L. The linearity was distinguished over the concentration range of QTP from 1 × 10^-7 to 1 × 10^-4 mol/L (calculated at 1030 cm^-1), with correlation coefficients (R²) of 0.9955. The presented AuNRs/MXene/NFs-based SERS strategy realizes QTP detection using SERS technology and provides a novel protocol for the therapeutic drug monitoring.

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基于AuNRs/MXene/NFs的三维SERS平台测定尿中喹硫平。

人类抗精神病药物的测定对个体化治疗和治疗药物监测具有重要意义。喹硫平（QTP）作为一种新型抗精神病药物，如果使用不当，可能会对人体健康造成危害。在这项工作中，我们合成了三维（3D）金纳米棒/MXene (Ti3C2Tx)/镍泡沫（命名为AuNRs/MXene/NFs）复合材料，用于检测抗精神病药物QTP。将制备的带负电荷的MXene通过静电相互作用组装在NFs表面形成MXene/NFs，然后将制备的aunr固定在MXene/NFs上，得到最终的3D aunr /MXene/NFs。利用NFs的多孔结构和磁性能、MXene的大比表面积和Au纳米棒的等离子体热点，基于AuNRs/MXene/NFs的SERS平台可以方便、灵敏地检测人尿中的QTP，检出限为1.71 × 10-9 mol/L。QTP的浓度范围为1 × 10-7 ~ 1 × 10-4 mol/L（以1030 cm-1计算），相关系数（R2）为0.9955。提出的基于AuNRs/MXene/ nfs的SERS策略利用SERS技术实现了QTP检测，为治疗药物监测提供了一种新的方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.