¹H, ¹³C and ¹⁵N backbone resonance assignment of the catalytic domain of human PTPN22.

IF 0.8 4区生物学 Q4 BIOPHYSICS

Biomolecular NMR Assignments Pub Date : 2025-04-25 DOI:10.1007/s12104-025-10233-6

Bryan T Martin, Michael W Clarkson, Ping Wu, Paola Di Lello

引用次数: 0

Abstract

Protein Tyrosine Phosphatase Non-receptor type 22 (PTPN22) is a tyrosine-phosphatase that plays a major role in inhibiting T-cell activation in immune cells. Recent studies have revealed that downregulation of PTPN22 triggers T-cell activation and enhances antitumor immune response, thereby identifying PTPN22 as a potential pharmacological target in cancer-immunology.Here we report the ¹H, ¹⁵N and ¹³C backbone resonance assignment for the 35.6 kDa catalytic domain of human PTPN22. This assignment will provide an essential experimental tool to identify and characterize potential PTPN22 inhibitors.

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人PTPN22催化结构域的1H， 13C和15N骨架共振分配。

蛋白酪氨酸磷酸酶非受体22型（PTPN22）是一种酪氨酸-磷酸酶，在免疫细胞中抑制t细胞活化起主要作用。最近的研究表明，下调PTPN22可触发t细胞活化，增强抗肿瘤免疫反应，从而确定PTPN22是癌症免疫学中的潜在药理靶点。在这里，我们报道了人类PTPN22 35.6 kDa催化结构域的1H， 15N和13C骨干共振分配。这项任务将提供一个必要的实验工具来识别和表征潜在的PTPN22抑制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomolecular NMR Assignments 生物-光谱学

CiteScore

1.70

自引率

11.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomolecular NMR Assignments provides a forum for publishing sequence-specific resonance assignments for proteins and nucleic acids as Assignment Notes. Chemical shifts for NMR-active nuclei in macromolecules contain detailed information on molecular conformation and properties. Publication of resonance assignments in Biomolecular NMR Assignments ensures that these data are deposited into a public database at BioMagResBank (BMRB; http://www.bmrb.wisc.edu/), where they are available to other researchers. Coverage includes proteins and nucleic acids; Assignment Notes are processed for rapid online publication and are published in biannual online editions in June and December.

1H, 13C and 15N backbone resonance assignment of the catalytic domain of human PTPN22.

Abstract

¹H, ¹³C and ¹⁵N backbone resonance assignment of the catalytic domain of human PTPN22.