Prevalence and resistance patterns of Mycoplasma genitalium infection in people living with HIV: a systematic review and meta-analysis.

IF 3.4 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2025-04-22 DOI:10.1097/QAD.0000000000004219

Rui Zhang, Sze Long Chung, Shui Shan Lee, Ngai Sze Wong

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引用次数: 0

Abstract

Objectives: This study aimed to estimate the prevalence of M. genitalium infection and understand the patterns of resistance associated mutations (resistance hereafter) in people living with HIV (PLWH).

Methods: We searched PubMed-MEDLINE, Embase and Web of Science to identify studies published as of 31st December 2023, reporting the prevalence of M. genitalium infection in PLWH. The pooled prevalence of M. genitalium infection and its resistance was calculated using random-effect models.

Results: Totally 66 studies involving 22,763 PLWH were included, with 5 studies reporting resistance. The overall pooled prevalence of M. genitalium infection in PLWH was 12% (95%CI: 9%-14%), which differed across geographic regions (P < 0.01), with the highest observed in North America (20%, 95%CI: 10%-32%). The pooled prevalence was the highest in female sex workers (FSW) living with HIV (20%, 95%CI: 10%-32%), but without statistical difference between different population groups (P = 0.76). The pooled prevalence of macrolide resistance-mediating mutations (MRMMs), quinolone resistance-determining regions (QRDRs) mutations, and multidrug resistance with MRMMs and QRDRs mutations in PLWH was 36% (95%CI: 5%-77%), 25% (95%CI: 8%-47%), and 20% (95%CI: 12%-29%), respectively.

Conclusion: The prevalence of M. genitalium infection in PLWH in this study was lower than HIV pre-exposure prophylaxis users and FSW, but higher than men who have sex with men in the community. There's substantial geographic variation in the prevalence of M. genitalium infection in PLWH. The variability reflects differences in exposure risks as well as the testing/treatment strategies in place for sexually transmitted infections.

Prospero registration number: CRD42023480798.

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HIV感染者生殖器支原体感染的流行和耐药模式：一项系统综述和荟萃分析。

目的：本研究旨在估计HIV感染者（PLWH）中生殖道支原体感染的患病率，并了解耐药相关突变（以下简称耐药）的模式。方法：我们检索PubMed-MEDLINE、Embase和Web of Science，以确定截至2023年12月31日发表的报告PLWH中生殖道支原体感染流行的研究。采用随机效应模型计算生殖支原体感染的总流行率及其耐药性。结果：共纳入66项研究，涉及22,763例PLWH，其中5项研究报告了耐药性。PLWH中生殖器支原体感染的总流行率为12% (95%CI: 9%-14%)，在不同地理区域存在差异(P结论：本研究中PLWH中生殖器支原体感染的流行率低于HIV暴露前预防使用者和FSW，但高于社区中男男性行为者。生殖支原体感染的流行在公共卫生机构中存在显著的地理差异。这种差异反映了暴露风险的差异以及性传播感染的检测/治疗策略。普洛斯彼罗注册号：CRD42023480798。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.