Real-life diagnostic performance and clinical impact of the BIOFIRE Joint Infection Panel in joint infections.

IF 3.3 4区医学 Q1 Medicine

European review for medical and pharmacological sciences Pub Date : 2025-04-01 DOI:10.26355/eurrev_202504_37167

S Kaoual, H Ernandes, R Rezgui, Y Ben Lamine, H Aouel, Y Chaaba, S Sallem, A Bellaaj, I Kooli, S Bouhalila Besbes

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引用次数: 0

Abstract

OBJECTIVE: Rapid and accurate pathogen identification is critical for the effective management of native septic arthritis (NSA) and periprosthetic joint infections (PJIs), enabling timely, targeted antimicrobial therapy and improving patient outcomes. This study aimed to evaluate the diagnostic performance and clinical relevance of the BIOFIRE Joint Infection Panel (BJIP) in NSA and PJI. MATERIALS AND METHODS: A prospective investigation was conducted, including samples from patients with suspected NSA and PJI. The diagnostic performance and turnaround time of BJIP were compared to conventional culture methods, with an additional analysis of BJIP's clinical impact. RESULTS: A total of 80 patients were included. The BJIP displayed a higher sensitivity (67%) compared to conventional culture (47%), albeit without any statistical significance (p = 0.078), and a specificity of 94%. Total percent agreement was estimated at 66% ( = 0.36). The combination of BJIP and culture significantly improved sensitivity (74%) compared to conventional culture alone (p = 0.0001) or BJIP alone (p = 0.03). BJIP sensitivity was 57% in NSA and 72% in PJI, with a higher sensitivity observed in late acute PJI (90%) compared to early acute (60%) and chronic PJI (33%). However, this difference was not statistically significant (p = 0.122). Among patients with prior antibiotic therapy, BJIP exhibited significantly higher sensitivity than conventional culture (68% vs. 35%, p = 0.006). BJIP also reduced the turnaround time for pathogen detection by 83 hours. Retrospective analysis suggested a BJIP-based clinical management improvement among 31% of infected and 50% of uninfected individuals. CONCLUSIONS: Our study demonstrated a high sensitivity and specificity of BJIP in diagnosing joint infections. The combination of BJIP and conventional culture emerged as an optimal diagnostic approach. BJIP outperformed conventional culture among patients with prior antibiotic treatment, substantially reduced the turnaround time for pathogen identification, and showed potential for improving clinical management.

Graphical abstract: https://www.europeanreview.org/wp/wp-content/uploads/Graphical-abstract-1.png.

查看原文本刊更多论文

BIOFIRE关节感染面板在关节感染中的实际诊断性能和临床影响。

目的：快速准确的病原体鉴定对于有效管理原生脓毒性关节炎（NSA）和假体周围关节感染（PJIs）至关重要，能够及时、有针对性地进行抗菌治疗，改善患者预后。本研究旨在评价BIOFIRE联合感染面板（BJIP）在NSA和PJI中的诊断性能和临床意义。材料和方法：进行前瞻性调查，包括疑似NSA和PJI患者的样本。将BJIP的诊断性能和周转时间与常规培养方法进行比较，并对BJIP的临床影响进行额外分析。结果：共纳入80例患者。与传统培养（47%）相比，BJIP显示出更高的敏感性（67%），尽管没有任何统计学意义（p = 0.078），特异性为94%。总的一致百分比估计为66%（= 0.36）。与单独使用常规培养（p = 0.0001）或单独使用BJIP （p = 0.03）相比，BJIP与培养联合使用可显著提高灵敏度（74%）。BJIP对NSA的敏感性为57%，对PJI的敏感性为72%，其中急性PJI晚期（90%）的敏感性高于急性早期（60%）和慢性PJI（33%）。但差异无统计学意义（p = 0.122）。在既往接受过抗生素治疗的患者中，BJIP的敏感性明显高于常规培养（68%对35%，p = 0.006）。BJIP还将病原体检测的周转时间缩短了83小时。回顾性分析表明，基于bjip的临床管理改善了31%的感染者和50%的未感染者。结论：我们的研究表明BJIP在诊断关节感染方面具有很高的敏感性和特异性。BJIP和常规培养的结合是一种最佳的诊断方法。在接受过抗生素治疗的患者中，BJIP优于传统培养，大大缩短了病原体鉴定的周转时间，并显示出改善临床管理的潜力。图形摘要：https://www.europeanreview.org/wp/wp-content/uploads/Graphical-abstract-1.png。

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来源期刊

European review for medical and pharmacological sciences 医学-药学

CiteScore

5.30

自引率

6.10%

发文量

906

审稿时长

2-4 weeks

期刊介绍： European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research. The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine. European Review for Medical and Pharmacological Sciences includes: -Editorials- Reviews- Original articles- Trials- Brief communications- Case reports (only if of particular interest and accompanied by a short review)