Trace element content is associated with urolith type in goats and pigs diagnosed with urolithiasis.

IF 1.3 3区农林科学 Q2 VETERINARY SCIENCES

American journal of veterinary research Pub Date : 2025-04-23 DOI:10.2460/ajvr.25.01.0011

Munashe Chigerwe, David W Killilea, Caitlin N Hardgrove, Uday Mann, Marshall L Stoller, Jodi L Westropp

{"title":"Trace element content is associated with urolith type in goats and pigs diagnosed with urolithiasis.","authors":"Munashe Chigerwe, David W Killilea, Caitlin N Hardgrove, Uday Mann, Marshall L Stoller, Jodi L Westropp","doi":"10.2460/ajvr.25.01.0011","DOIUrl":null,"url":null,"abstract":"Objective: To determine the urolith trace elemental profile and the association of these elements with urolith type and animal variables.Methods: This was a cross-sectional study of 165 goat and 50 pig uroliths collected from urinary bladders from January 1, 1982, through December 31, 2020. Urolith mineral composition was determined using polarized light microscopy and infrared spectroscopy. Trace element analysis was determined by inductively coupled plasma optical emission spectrometry. The association between animal variables and trace element content was assessed. The strength of grouping effects of the elements within the uroliths was determined by cluster analysis.Results: Calcium carbonate (74 of 116 [63%]) and apatite (22 of 47 [47%]) were the most commonly identified urolith types in goats and pigs, respectively. The element with the highest concentrations in calcium carbonate uroliths in goats was calcium. Apatite-containing uroliths from pigs had phosphorous as the highest concentration element. Large goat breeds (OR, 1.2; 95% CI, 1.1 to 1.4) and non-pot-bellied pigs had higher odds (OR, 1.6; 95% CI, 1.2 to 2.0) of detection of trace elements. The combination of barium, calcium, sodium, and strontium in goats defined the most significant dissimilarity (divergence) within the calcium carbonate uroliths. In pigs, boron, potassium, sodium, and strontium combination defined the most significant dissimilarity within the apatite uroliths.Conclusions: Trace elements in combinations that defined significant dissimilarity among uroliths suggest an association between trace elements and urolith type.Clinical relevance: Trace and macroelements should be analyzed in uroliths and feed to optimize dietary recommendations for urolithiasis prevention.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3000,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of veterinary research","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.2460/ajvr.25.01.0011","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To determine the urolith trace elemental profile and the association of these elements with urolith type and animal variables.

Methods: This was a cross-sectional study of 165 goat and 50 pig uroliths collected from urinary bladders from January 1, 1982, through December 31, 2020. Urolith mineral composition was determined using polarized light microscopy and infrared spectroscopy. Trace element analysis was determined by inductively coupled plasma optical emission spectrometry. The association between animal variables and trace element content was assessed. The strength of grouping effects of the elements within the uroliths was determined by cluster analysis.

Results: Calcium carbonate (74 of 116 [63%]) and apatite (22 of 47 [47%]) were the most commonly identified urolith types in goats and pigs, respectively. The element with the highest concentrations in calcium carbonate uroliths in goats was calcium. Apatite-containing uroliths from pigs had phosphorous as the highest concentration element. Large goat breeds (OR, 1.2; 95% CI, 1.1 to 1.4) and non-pot-bellied pigs had higher odds (OR, 1.6; 95% CI, 1.2 to 2.0) of detection of trace elements. The combination of barium, calcium, sodium, and strontium in goats defined the most significant dissimilarity (divergence) within the calcium carbonate uroliths. In pigs, boron, potassium, sodium, and strontium combination defined the most significant dissimilarity within the apatite uroliths.

Conclusions: Trace elements in combinations that defined significant dissimilarity among uroliths suggest an association between trace elements and urolith type.

Clinical relevance: Trace and macroelements should be analyzed in uroliths and feed to optimize dietary recommendations for urolithiasis prevention.

查看原文本刊更多论文

微量元素含量与诊断为尿石症的山羊和猪的尿石类型有关。

目的：了解尿石微量元素分布及其与尿石类型和动物变量的关系。方法：这是一项横断面研究，收集了1982年1月1日至2020年12月31日期间165只山羊和50只猪的膀胱尿石。用偏光显微镜和红外光谱法测定尿石矿物组成。采用电感耦合等离子体发射光谱法测定微量元素。评估了动物变量与微量元素含量之间的关系。通过聚类分析确定尿石内元素的分组效应强度。结果：山羊和猪最常见的尿石类型分别为碳酸钙（116例中有74例[63%]）和磷灰石（47例中有22例[47%]）。山羊碳酸钙尿石中含量最高的元素是钙。含磷灰石的猪尿石中磷元素含量最高。大型山羊品种(OR, 1.2；95% CI, 1.1 - 1.4)和非大肚猪的几率更高(OR, 1.6；95% CI, 1.2 ~ 2.0)的微量元素检测。山羊的钡、钙、钠和锶的组合定义了碳酸钙尿石中最显著的差异（差异）。在猪中，硼、钾、钠和锶的组合定义了磷灰石尿石中最显著的差异。结论：微量元素组合在尿石中定义了显著的差异，表明微量元素与尿石类型之间存在关联。临床相关性：应分析尿石和饲料中的微量元素和常量元素，以优化预防尿石症的饮食建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

American journal of veterinary research 农林科学-兽医学

CiteScore

1.70

自引率

10.00%

发文量

186

审稿时长

3 months

期刊介绍： The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.