Intraflagellar Transport (IFT) and Sperm Formation.

4区医学 Q2 Biochemistry, Genetics and Molecular Biology

Advances in experimental medicine and biology Pub Date : 2025-01-01 DOI:10.1007/978-3-031-82990-1_17

Yunhao Liu, Yu Fang, Opeyemi Dhikhirullahi, Ling Zhang, Zhibing Zhang

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Abstract

Intraflagellar transport (IFT) is a conserved mechanism for cilia formation. Twenty-two IFT components form the IFT-A complex (six components) and IFT-B complex (sixteen components). Driven by kinesin and dynein motor proteins, these IFT complexes are involved in the trafficking of proteins needed for cilia assembly by anterograde transport and retrograde transport. IFT core components also associate with other proteins for cilia formation. Mutations in IFT core components result in ciliogenesis defects and human diseases, including male infertility. Sperm flagella are specialized motile cilia that not only have core axoneme structure but also possess accessory structures. IFT is required to assemble these structures to form functional sperm. This summary highlights the regulatory roles of specific IFT proteins in spermatogenesis. A deeper understanding of IFT-related mechanisms can shed light on the etiology and pathophysiology of certain male infertility cases, as well as provide insights for the development of novel male contraceptives.

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鞭毛内运输（IFT）与精子形成。

鞭毛内转运（IFT）是纤毛形成的一种保守机制。22个IFT组分组成了IFT- a复合物（6个组分）和IFT- b复合物（16个组分）。这些IFT复合物由动力蛋白和动力蛋白驱动，通过顺行和逆行运输参与纤毛组装所需蛋白质的运输。IFT核心成分还与其他蛋白质结合，形成纤毛。IFT核心成分的突变导致纤毛发育缺陷和人类疾病，包括男性不育。精子鞭毛是一种特殊的活动纤毛，不仅具有核心轴素结构，而且具有附属结构。IFT需要将这些结构组装起来，形成功能性精子。本综述强调了特异性IFT蛋白在精子发生中的调节作用。对ift相关机制的深入了解，有助于揭示某些男性不育症的病因和病理生理，并为新型男性避孕药的开发提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in experimental medicine and biology 医学-医学：研究与实验

CiteScore

5.90

自引率

0.00%

发文量

465

审稿时长

2-4 weeks

期刊介绍： Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.