Serum Copper Levels in Chronic Kidney Disease and Hemodialysis Patients: Insights from a Systematic Review and Meta-Analysis.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biological Trace Element Research Pub Date : 2025-04-30 DOI:10.1007/s12011-025-04647-5

Abdullah Yousef Aldalati, Ayham Mohammad Hussein, Elsayed Balbaa, Bassel Alrabadi, Moath Albliwi, Mohammad Abuassi, Badi Rawashdeh

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引用次数: 0

Abstract

Background: Copper is an essential trace element involved in numerous enzymatic functions and physiological processes. Chronic kidney disease (CKD) and hemodialysis (HD) may influence copper homeostasis, yet conflicting findings exist regarding copper levels in these patients and copper levels aren't routinely checked. This systematic review and meta-analysis evaluates serum copper concentrations in CKD and HD patients compared to healthy controls (HC), and assesses changes pre- and post-HD.

Methods: A systematic search of PubMed, Scopus, Cochrane Library, EMBASE, and Web of Science was conducted up to February 2025. Observational studies reporting serum copper levels in CKD and HD patients were included. Data analysis were conducted using RevMan software. The data were pooled as standardized mean difference (SMD) and using a random-effects model.

Results: A total of 42 studies with 13,592 participants were included. No significant difference in copper levels was observed between CKD patients and HC (SMD: -0.18, 95% CI: -1.17, 0.80; P = 0.71). However, HD patients had significantly lower copper levels compared to HC (SMD: -0.48, 95% CI: -0.89, -0.07; P = 0.02). Additionally, HD significantly reduced serum copper levels post-treatment compared to pre-HD (SMD: -0.41, 95% CI: -0.62, -0.21; P < 0.0001).

Conclusion: Our findings suggest that CKD does not significantly impact serum copper levels, whereas HD leads to a significant decrease in copper concentrations. The mechanisms underlying this reduction require further elucidation, and future studies should explore the potential clinical consequences of low copper levels in HD patients.

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慢性肾脏疾病和血液透析患者的血清铜水平：来自系统回顾和荟萃分析的见解

背景：铜是一种必需的微量元素，参与许多酶的功能和生理过程。慢性肾脏疾病（CKD）和血液透析（HD）可能会影响铜稳态，但这些患者体内的铜水平存在矛盾的发现，而且没有常规检查铜水平。本系统综述和荟萃分析评估了CKD和HD患者与健康对照组（HC）相比的血清铜浓度，并评估了HD前后的变化。方法：系统检索截至2025年2月的PubMed、Scopus、Cochrane Library、EMBASE和Web of Science数据库。报告CKD和HD患者血清铜水平的观察性研究被纳入。使用RevMan软件进行数据分析。数据采用标准化平均差（SMD）合并，采用随机效应模型。结果：共纳入42项研究，13592名受试者。CKD患者和HC患者铜水平无显著差异(SMD: -0.18, 95% CI: -1.17, 0.80；p = 0.71)。然而，与HC相比，HD患者的铜水平显著降低(SMD: -0.48, 95% CI: -0.89, -0.07；p = 0.02)。此外，与HD前相比，HD治疗后显著降低了血清铜水平(SMD: -0.41, 95% CI: -0.62, -0.21；结论：我们的研究结果表明CKD不会显著影响血清铜水平，而HD会导致铜浓度显著降低。这种减少的机制需要进一步阐明，未来的研究应该探索低铜水平在HD患者中的潜在临床后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Trace Element Research 生物-内分泌学与代谢

CiteScore

8.70

自引率

10.30%

发文量

459

审稿时长

2 months

期刊介绍： Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.