Comparison and cutoff values of two amyloid PET scaling methods: centiloid scale and amyloid-β load.

IF 2.5 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Annals of Nuclear Medicine Pub Date : 2025-08-01 Epub Date: 2025-04-26 DOI:10.1007/s12149-025-02051-6

Ryo Yamakuni, Mitsunari Abe, Naoyuki Ukon, Hiroshi Matsuda, Harumasa Takano, Nobukatsu Sawamoto, Atsushi Shima, Yuhei Mori, Hirofumi Sekino, Shiro Ishii, Kenji Fukushima, Toshiki Mizuno, Jin Narumoto, Takashi Hanakawa, Hiroshi Ito

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引用次数: 0

Abstract

Objective: To enhance amyloid-β (Aβ) positron emission tomography (PET) diagnostic accuracy and adjust for tracer differences, the amyloid-β load (Aβ_L) and centiloid (CL) scale were developed. However, the correlation and superiority of these indicators remain unclear. This study aimed to elucidate the correlation and determine cutoff values.

Methods: Data from 281 consecutive participants (144 males; mean age, 69.6 years) in the Parkinson's and Alzheimer's Disease Dimensional Neuroimaging Initiative study were analyzed. Initial data, including Aβ PET, structural MRI, and Global Clinical Dementia Rating (G-CDR) scores, were reviewed. CL was calculated using the cerebral cortical and striatum Volume of Interest templates (VOI) and whole cerebellum VOI. Aβ_L was calculated using voxel-wise regression with two canonical images representing non-displaceable and specific binding. Visual estimation was performed by five radiologists, with two independently classify as visual-only Aβ-negative or Aβ-positive. The discrepancies were resolved through majority consensus involving a third observer. Additional visual estimation was performed for cases with CL value under 10 but visual-only Aβ-positive, and those over 30 but Aβ-negative, by two nuclear medicine radiologists. The discrepancies were resolved through discussion and classify as final Aβ diagnosis negative or positive.

Results: CL and Aβ_L correlated linearly (CL = Aβ_L × 2.10-9.40, R² = 0.923). In predicting final Aβ diagnosis negative versus positive, both CL (AUC = 0.996) and Aβ_L (AUC = 0.997) were significant, with no significant differences (P = 0.882). The Youden Index was 23.3 for CL and 15.6 for Aβ_L. In predicting cognitively normal participants (G-CDR = 0) from others, both CL (AUC = 0.687) and Aβ_L (AUC = 0.667) were significant, with no significant differences (P = 0.379). The Youden Index was 11.9 for CL and 11.6 for Aβ_L. Using a non-biased Gaussian mixture model, the normal group's mean and SD were -2.5 (SD = 6.5) for CL and 3.7 (SD = 3.0) for Aβ_L, resulting in 95% limits (mean + 2SD) of 10.4 for CL and 9.7 for Aβ_L.

Conclusions: This study demonstrated a high correlation and non-inferiority between CL and Aβ_L.

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两种淀粉样PET标度方法：centiloid scale和amyloid-β load的比较及截止值。

目的：为了提高淀粉样蛋白-β (Aβ)正电子发射断层扫描（PET）的诊断准确性，调整示踪剂差异，建立了淀粉样蛋白-β负荷（Aβ l）和centiloid （CL）量表。然而，这些指标的相关性和优越性尚不清楚。本研究旨在阐明相关性并确定截止值。方法：数据来自281名连续参与者(144名男性；在帕金森病和阿尔茨海默病维度神经成像倡议研究中，平均年龄69.6岁)进行分析。我们回顾了包括β PET、结构MRI和全球临床痴呆评分（G-CDR）在内的初始数据。利用大脑皮层和纹状体感兴趣体积模板（VOI）和整个小脑VOI计算CL。AβL使用体素回归计算，两个典型图像代表不可置换和特定结合。视觉评估由五名放射科医生进行，其中两名独立分类为仅视觉a β阴性或a β阳性。这些差异通过由第三名观察员参与的多数协商一致意见得到解决。2名核医学放射科医师对CL值小于10但视觉上仅为a β阳性的病例和CL值大于30但视觉上仅为a β阴性的病例进行额外的视觉估计。通过讨论解决差异，并将最终的Aβ诊断分为阴性或阳性。结果：CL与AβL呈线性相关（CL = AβL × 2.10 ~ 9.40, R2 = 0.923）。在预测最终Aβ诊断阴性与阳性时，CL （AUC = 0.996）和Aβ l （AUC = 0.997）均有统计学意义，差异无统计学意义（P = 0.882）。CL和AβL的约登指数分别为23.3和15.6。在预测其他认知正常参与者（G-CDR = 0）时，CL （AUC = 0.687）和a - β l （AUC = 0.667）均有显著性差异（P = 0.379）。CL和AβL的约登指数分别为11.9和11.6。使用无偏高斯混合模型，正常组CL的平均值和SD为-2.5 (SD = 6.5)， a β l的平均值和SD为3.7 (SD = 3.0)，导致CL和a β l的95%限（平均值+ 2SD）分别为10.4和9.7。结论：本研究表明CL与a β l具有高度的相关性和非劣效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Nuclear Medicine 医学-核医学

CiteScore

4.90

自引率

7.70%

发文量

111

审稿时长

4-8 weeks

期刊介绍： Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.