{"title":"Cytologic Diagnosis of Lymphomatoid Granulomatosis, A Case Report and Review of the Literature","authors":"Mohamed Eltahir, Javeryah Safi, Brant G. Wang","doi":"10.1002/dc.25475","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Lymphomatoid granulomatosis (LYG) is a rare EBV-driven, extra-nodal, angiocentric, and angio-destructive lymphoproliferative disorder. The lungs are the most common site of involvement. We describe a case of LYG where the diagnosis was established based on fine needle aspiration. The case is of a 58-year-old female with a history of endometrial carcinoma, who presented with right upper lobe and right middle lobe pulmonary nodules which were identified on a surveillance computed tomography (CT) scan of the chest. The patient underwent an endobronchial ultrasound-guided fine needle aspiration, and a cytologic examination showed mixed inflammatory infiltrate with histiocyte and small lymphocyte predominance and scattered large atypical cells. Immunohistochemical analysis showed that the large atypical cells were positive for CD30, PAX5, and MUM1. In situ hybridization for Epstein–Barr virus-encoded RNA was found to be positive in the atypical cells. The patient was started on treatment with peginterferon alfa-2a. We also discuss the differential diagnosis of LYG and review the available literature.</p>\n </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 7","pages":"E127-E132"},"PeriodicalIF":1.0000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic Cytopathology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/dc.25475","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Lymphomatoid granulomatosis (LYG) is a rare EBV-driven, extra-nodal, angiocentric, and angio-destructive lymphoproliferative disorder. The lungs are the most common site of involvement. We describe a case of LYG where the diagnosis was established based on fine needle aspiration. The case is of a 58-year-old female with a history of endometrial carcinoma, who presented with right upper lobe and right middle lobe pulmonary nodules which were identified on a surveillance computed tomography (CT) scan of the chest. The patient underwent an endobronchial ultrasound-guided fine needle aspiration, and a cytologic examination showed mixed inflammatory infiltrate with histiocyte and small lymphocyte predominance and scattered large atypical cells. Immunohistochemical analysis showed that the large atypical cells were positive for CD30, PAX5, and MUM1. In situ hybridization for Epstein–Barr virus-encoded RNA was found to be positive in the atypical cells. The patient was started on treatment with peginterferon alfa-2a. We also discuss the differential diagnosis of LYG and review the available literature.
期刊介绍：
Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.
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