{"title":"Dive into the bone: new insights into molecular mechanisms of cancer bone invasion.","authors":"Masayuki Tsukasaki","doi":"10.1093/jbmr/zjaf054","DOIUrl":null,"url":null,"abstract":"<p><p>Cancer-bone interactions have been investigated primarily in the context of bone metastasis. However, hematogenous spread is not the only route by which cancer cells enter the bone. Certain types of cancer, including head and neck squamous cell carcinoma (HNSCC), directly invade the bone tissue because of the close anatomical relationship between the bone and primary lesions. This type of invasion significantly worsens prognosis and quality of life; however, comparatively less attention has been paid to the mechanisms of primary tumor-related bone invasion. A recent study demonstrated that the periosteum thickens in response to the proximity of tumors and functions as a physical barrier against tumor progression. Periosteum thickening occurs at the pre-invasive stage, a key time point that has been overlooked in previous studies, and critically contributes to the inhibition of cancer invasion into the bone. This study provides insights into the mechanisms of localized bone invasion by cancer, highlights the anti-tumor effects of non-immune stromal cells, and offers a new concept of \"stromal defense against cancer,\" extending the horizon of cancer biology. Here, I discuss the tumor-host interactions during multiple steps of cancer invasion into the bone and how the emerging concepts from bone research contribute to the understanding of the pathogenesis and development of new therapeutic strategies for malignancies in the bone and beyond.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"827-833"},"PeriodicalIF":5.9000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bone and Mineral Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jbmr/zjaf054","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Cancer-bone interactions have been investigated primarily in the context of bone metastasis. However, hematogenous spread is not the only route by which cancer cells enter the bone. Certain types of cancer, including head and neck squamous cell carcinoma (HNSCC), directly invade the bone tissue because of the close anatomical relationship between the bone and primary lesions. This type of invasion significantly worsens prognosis and quality of life; however, comparatively less attention has been paid to the mechanisms of primary tumor-related bone invasion. A recent study demonstrated that the periosteum thickens in response to the proximity of tumors and functions as a physical barrier against tumor progression. Periosteum thickening occurs at the pre-invasive stage, a key time point that has been overlooked in previous studies, and critically contributes to the inhibition of cancer invasion into the bone. This study provides insights into the mechanisms of localized bone invasion by cancer, highlights the anti-tumor effects of non-immune stromal cells, and offers a new concept of "stromal defense against cancer," extending the horizon of cancer biology. Here, I discuss the tumor-host interactions during multiple steps of cancer invasion into the bone and how the emerging concepts from bone research contribute to the understanding of the pathogenesis and development of new therapeutic strategies for malignancies in the bone and beyond.
期刊介绍:
The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases.