Dive into the bone: new insights into molecular mechanisms of cancer bone invasion.

IF 5.9 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Masayuki Tsukasaki
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Abstract

Cancer-bone interactions have been investigated primarily in the context of bone metastasis. However, hematogenous spread is not the only route by which cancer cells enter the bone. Certain types of cancer, including head and neck squamous cell carcinoma (HNSCC), directly invade the bone tissue because of the close anatomical relationship between the bone and primary lesions. This type of invasion significantly worsens prognosis and quality of life; however, comparatively less attention has been paid to the mechanisms of primary tumor-related bone invasion. A recent study demonstrated that the periosteum thickens in response to the proximity of tumors and functions as a physical barrier against tumor progression. Periosteum thickening occurs at the pre-invasive stage, a key time point that has been overlooked in previous studies, and critically contributes to the inhibition of cancer invasion into the bone. This study provides insights into the mechanisms of localized bone invasion by cancer, highlights the anti-tumor effects of non-immune stromal cells, and offers a new concept of "stromal defense against cancer," extending the horizon of cancer biology. Here, I discuss the tumor-host interactions during multiple steps of cancer invasion into the bone and how the emerging concepts from bone research contribute to the understanding of the pathogenesis and development of new therapeutic strategies for malignancies in the bone and beyond.

深入骨骼:癌症骨侵袭分子机制的新见解。
癌症-骨相互作用的研究主要是在骨转移的背景下进行的。然而,血液扩散并不是癌细胞进入骨骼的唯一途径。某些类型的癌症,包括头颈部鳞状细胞癌(HNSCC),由于骨骼与原发病变之间的密切解剖关系,直接侵犯骨组织。这种类型的侵袭显著恶化预后和生活质量;然而,对原发性肿瘤相关骨侵袭机制的研究相对较少。最近的一项研究表明,骨膜增厚响应肿瘤的接近和功能作为一个物理屏障,以防止肿瘤进展。骨膜增厚发生在侵袭前阶段,这是一个在以往的研究中被忽视的关键时间点,对抑制癌症对骨的侵袭至关重要。本研究揭示了肿瘤局部侵袭骨的机制,突出了非免疫基质细胞的抗肿瘤作用,提出了“基质防御癌症”的新概念,拓展了癌症生物学的视野。在这里,我讨论了肿瘤侵袭骨骼的多个步骤中肿瘤与宿主的相互作用,以及骨骼研究中新兴的概念如何有助于理解骨骼及其他恶性肿瘤的发病机制和新治疗策略的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Bone and Mineral Research
Journal of Bone and Mineral Research 医学-内分泌学与代谢
CiteScore
11.30
自引率
6.50%
发文量
257
审稿时长
2 months
期刊介绍: The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases.
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