Advances in the Localization and Regulation of P-glycoprotein in Different Tissues and Organs.

Q4 Medicine

中国医学科学院学报 Pub Date : 2025-04-30 DOI:10.3881/j.issn.1000-503X.16156

Jia-Hua Zhao, Xiao-Sa Yang, Xiao-Jiao Xu, Rui Liu, Tian-Tian Zhuang, Jia-Tang Zhang

引用次数: 0

Abstract

P-glycoprotein(P-gp)is an ATP-dependent efflux transporter that is distributed in many tissues and organs.P-gp can selectively pump endogenous substrates and exogenous chemicals from the cell to the outside of the cell to maintain a stable endo-environment.However,it meanwhile restricts the entry of therapeutic drug into tissues and organs,and in particular,mediates the multidrug resistance of tumor cells to chemotherapeutic drugs.Therefore,understanding the localization of P-gp in different tissues and organs may be an important breakthrough point for disease treatment.In this paper,we mainly review the molecular structure,transport mechanism,localization,and regulation of P-gp in different tissues and organs,providing reference for the subsequent treatment of diseases.

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p -糖蛋白在不同组织器官中的定位与调控研究进展。

p -糖蛋白（P-gp）是一种atp依赖的外排转运蛋白，分布在许多组织和器官中。P-gp可以选择性地将内源性底物和外源性化学物质从细胞内泵送到细胞外，以维持细胞内环境的稳定。但同时也限制了治疗药物进入组织和器官，特别是介导肿瘤细胞对化疗药物的多药耐药。因此，了解P-gp在不同组织和器官中的定位可能是疾病治疗的重要突破点。本文主要综述P-gp在不同组织器官中的分子结构、转运机制、定位及调控，为后续疾病的治疗提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国医学科学院学报 Medicine-Medicine (all)

CiteScore

0.60

自引率

0.00%

发文量

6813

期刊介绍： Acta Academiae Medicinae Sinicae was founded in February 1979. It is a comprehensive medical academic journal published in China and abroad, supervised by the Ministry of Health of the People's Republic of China and sponsored by the Chinese Academy of Medical Sciences and Peking Union Medical College. The journal mainly reports the latest research results, work progress and dynamics in the fields of basic medicine, clinical medicine, pharmacy, preventive medicine, biomedicine, medical teaching and research, aiming to promote the exchange of medical information and improve the academic level of medicine. At present, the journal has been included in 10 famous foreign retrieval systems and their databases [Medline (PubMed online version), Elsevier, EMBASE, CA, WPRIM, ExtraMED, IC, JST, UPD and EBSCO-ASP]; and has been included in important domestic retrieval systems and databases [China Science Citation Database (Documentation and Information Center of the Chinese Academy of Sciences), China Core Journals Overview (Peking University Library), China Science and Technology Paper Statistical Source Database (China Science and Technology Core Journals) (China Institute of Scientific and Technological Information), China Science and Technology Journal Paper and Citation Database (China Institute of Scientific and Technological Information)].