PANoptosis: a potential target of atherosclerotic cardiovascular disease.

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Apoptosis Pub Date : 2025-04-26 DOI:10.1007/s10495-025-02089-x

Xiao Jin, Yanan Zhu, Lina Xing, Xinyue Ding, Zongjun Liu

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引用次数: 0

Abstract

PANoptosis is a newly discovered cell death pathway triggered by the innate immunizer, which in turn promotes the assembly of the PANoptosome and activates downstream effectors. As a special cell death mode, it is characterized by apoptosis, pyroptosis, and necroptosis at the same time; therefore, it is not feasible to inhibit PANoptosis by suppressing a single cell death pathway. However, active ingredients targeting the PANoptosome can effectively inhibit PANoptosis.Given the importance of cell death in disease, targeting PANoptosis would be an important therapeutic tool. Previous studies have focused more on infectious diseases and cancer, and the role of PANoptosis in the cardiovascular field has not been comprehensively addressed. While ASCVD is the number one killer of cardiovascular diseases, it is important to explore new targets to determine future research directions. Therefore, this review focuses on the assembly of PANoptosome, the molecular mechanism of PANoptosis, and the related mechanisms of PANoptosis leading to ASCVD such as myocardial infarction, ischemic cardiomyopathy and ischemic stroke, in order to provide a new perspective for the prevention and treatment of ASCVD.

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PANoptosis：动脉粥样硬化性心血管疾病的潜在靶点。

PANoptosis是一种新发现的由先天免疫因子触发的细胞死亡途径，它反过来促进PANoptosome的组装并激活下游效应物。它是一种特殊的细胞死亡方式，具有细胞凋亡、焦亡、坏死同时发生的特点；因此，通过抑制单细胞死亡途径来抑制PANoptosis是不可行的。而针对PANoptosome的活性成分可以有效抑制PANoptosis。鉴于细胞死亡在疾病中的重要性，靶向PANoptosis将是一种重要的治疗工具。以往的研究多集中在传染病和癌症方面，PANoptosis在心血管领域的作用尚未得到全面的探讨。ASCVD是心血管疾病的头号杀手，探索新的靶点以确定未来的研究方向十分重要。因此，本文就PANoptosome的组装、PANoptosis的分子机制以及PANoptosis导致心肌梗死、缺血性心肌病、缺血性脑卒中等ASCVD的相关机制进行综述，以期为ASCVD的预防和治疗提供新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Apoptosis 生物-生化与分子生物学

CiteScore

9.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.