Delivering a new generation of translational animal models for depression research.

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES
Behavioural Pharmacology Pub Date : 2025-06-01 Epub Date: 2025-05-07 DOI:10.1097/FBP.0000000000000819
Emma S J Robinson
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引用次数: 0

Abstract

Early animal models of depression focused on developing methods that could predict treatment efficacy and were validated based on pharmacological responses to known antidepressants. As our understanding of major depressive disorder (MDD) and the pharmacology of antidepressants progressed, so did the need for better animal models. This need was met with the development of new disease models, such as the chronic mild stress model, and behavioural readouts such as the sucrose preference test, which more closely aligned with risk factors and symptoms seen in patients. These approaches have supported huge advances in the understanding of how stress affects the brain and impacts on reward-related behaviours. However, there remain significant challenges when trying to model complex psychiatric symptoms and disorders in non-human animals. In this perspective article, a brief history of animal models of depression and associated readouts is discussed with specific reference to the important contributions from Paul Willner. The main discussion then focuses on translational validity and approaches that may support delivering this objective. This is illustrated with the example of the affective bias test and reward learning assays, which have been developed to recapitulate in animals the neuropsychological impairments observed in MDD and modulation by antidepressants.

为抑郁症研究提供新一代可转化的动物模型。
早期的抑郁症动物模型专注于开发能够预测治疗效果的方法,并根据已知抗抑郁药物的药理反应进行验证。随着我们对重度抑郁症(MDD)和抗抑郁药物药理学的了解不断深入,对更好的动物模型的需求也在不断增加。新的疾病模型(如慢性轻度压力模型)和行为读数(如蔗糖偏好测试)的发展满足了这一需求,这些模型与患者的风险因素和症状更紧密地联系在一起。这些方法在理解压力如何影响大脑和影响奖励相关行为方面取得了巨大进展。然而,当试图在非人类动物中模拟复杂的精神症状和疾病时,仍然存在重大挑战。在这篇前瞻性的文章中,简要介绍了抑郁症动物模型的历史和相关的读数,并特别提到了Paul Willner的重要贡献。然后主要的讨论集中在翻译的有效性和可能支持实现这一目标的方法上。情感偏差测试和奖励学习测试的例子说明了这一点,这些测试已经发展到概括在动物中观察到的重度抑郁症和抗抑郁药调节的神经心理障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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