Vascular endothelial growth factors in airway allergic diseases: pathophysiological functions and therapeutic prospects.

IF 3.9 3区医学 Q2 IMMUNOLOGY

Expert Review of Clinical Immunology Pub Date : 2025-04-28 DOI:10.1080/1744666X.2025.2499597

Yu Zhang, Jingyun Li, Luo Zhang, Yuan Zhang

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引用次数: 0

Abstract

Introduction: Vascular endothelial growth factors (VEGFs) play a crucial role in regulating physiological angiogenesis and homeostasis during growth and development. Recent advancements in our knowledge of VEGFs have revealed their complex role in coordinating vascular homeostasis and pathological role in various airway allergic reactions and structural remodeling, especially in allergic asthma and allergic rhinitis (AR), which has become more apparent.

Areas covered: After an extensive search of PubMed and Web of Science databases, our review covered articles published from 1989 to 2024. The purpose of this review was to review previous studies on VEGFs involved in inflammatory progression and tissue remodeling in airway allergic diseases, to summarize the relevant pathways. This article further reviews that VEGFs and their receptors can also be potential targets for treating airway allergic diseases.

Expert opinion: The prevalence of airway allergic diseases is increasing, which has caused a serious economic burden. VEGFs and their receptors have been recognized as potential targets for therapeutic interventions, which have been effectively applied in the treatment of tumors and other diseases. Fully elucidating the involvement of VEGFs in the disease process will help us understand their mechanisms of action and develop targeted therapies for allergic diseases.

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血管内皮生长因子在气道变应性疾病中的病理生理功能及治疗前景。

血管内皮生长因子（Vascular endothelial growth factors, vegf）在调节生长发育过程中的生理性血管生成和体内平衡中起着至关重要的作用。近年来，我们对血管内皮生长因子的研究进展揭示了它们在各种气道过敏反应和结构重塑中协调血管稳态和病理作用的复杂作用，特别是在过敏性哮喘和变应性鼻炎（AR）中，这一作用越来越明显。涵盖领域：经过对PubMed和Web of Science数据库的广泛搜索，我们的综述涵盖了1989年至2024年发表的文章。本综述的目的是回顾以往关于vegf参与气道变应性疾病炎症进展和组织重塑的研究，总结相关途径。本文进一步综述了vegf及其受体也可能是治疗气道变应性疾病的潜在靶点。专家意见：气道变态反应性疾病的患病率正在上升，这已经造成了严重的经济负担。vegf及其受体已被认为是治疗干预的潜在靶点，在肿瘤和其他疾病的治疗中得到了有效的应用。充分阐明vegf在疾病过程中的参与将有助于我们了解其作用机制，并开发针对过敏性疾病的靶向治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Clinical Immunology IMMUNOLOGY-

CiteScore

7.60

自引率

2.30%

发文量

221

审稿时长

6-12 weeks

期刊介绍： Expert Review of Clinical Immunology (ISSN 1744-666X) provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in clinical immunology. Members of the International Editorial Advisory Panel of Expert Review of Clinical Immunology are the forefront of their area of expertise. This panel works with our dedicated editorial team to identify the most important and topical review themes and the corresponding expert(s) most appropriate to provide commentary and analysis. All articles are subject to rigorous peer-review, and the finished reviews provide an essential contribution to decision-making in clinical immunology. Articles focus on the following key areas: • Therapeutic overviews of specific immunologic disorders highlighting optimal therapy and prospects for new medicines • Performance and benefits of newly approved therapeutic agents • New diagnostic approaches • Screening and patient stratification • Pharmacoeconomic studies • New therapeutic indications for existing therapies • Adverse effects, occurrence and reduction • Prospects for medicines in late-stage trials approaching regulatory approval • Novel treatment strategies • Epidemiological studies • Commentary and comparison of treatment guidelines Topics include infection and immunity, inflammation, host defense mechanisms, congenital and acquired immunodeficiencies, anaphylaxis and allergy, systemic immune diseases, organ-specific inflammatory diseases, transplantation immunology, endocrinology and diabetes, cancer immunology, neuroimmunology and hematological diseases.