Cardiovascular Outcomes After Acute Coronary Syndrome in Persons Living with HIV: A Scoping Review.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Cardiology Reports Pub Date : 2025-04-14 DOI:10.1007/s11886-024-02186-4

David Iskhakov, Julie N Deleger, Jorge Plutzky, Virginia A Triant, Emily P Hyle

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引用次数: 0

Abstract

Purpose of review: Over the past twenty-five years, a growing body of research has investigated outcomes after an acute coronary syndrome (ACS) event in persons with HIV (PWH). In this scoping review, we assessed the published literature on outcomes after a prior ACS event in PWH compared to persons without HIV (PWoH) in the US and Europe.

Recent findings: Of 27 studies of secondary prevention of cardiovascular disease, 15 studies found a greater incidence of recurrent ACS, heart failure, in-stent thrombosis, revascularization, restenosis, and mortality in PWH after a prior ACS event compared to PWoH. PWH were more likely to present with STEMI, less likely to receive percutaneous coronary intervention, and more likely to exhibit an active inflammatory state. The remaining 12 studies found no significant difference in outcomes after a prior ACS event. PWH may face an increased risk of adverse outcomes after ACS that differ in presentation and management compared with PWoH. Larger observational studies are needed to assess outcomes after a prior ACS event in PWH compared to PWoH and improve clinical management.

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艾滋病病毒感染者急性冠状动脉综合征后的心血管结局：一项范围综述

综述目的：在过去的25年里，越来越多的研究调查了HIV感染者（PWH）急性冠脉综合征（ACS）事件后的结果。在这一范围综述中，我们评估了美国和欧洲PWH患者与未感染HIV （PWoH）患者相比，先前发生ACS事件后的结果的已发表文献。最近发现：在27项心血管疾病二级预防研究中，15项研究发现，与PWoH相比，PWH在ACS事件后复发ACS、心力衰竭、支架内血栓形成、血运重建术、再狭窄和死亡率的发生率更高。PWH更有可能出现STEMI，更不可能接受经皮冠状动脉介入治疗，更有可能表现出活跃的炎症状态。其余12项研究未发现既往ACS事件后的结果有显著差异。与PWoH相比，PWH可能面临ACS后不同表现和处理的不良后果风险增加。需要更大规模的观察性研究来评估PWH患者与PWoH患者之前发生ACS事件后的结果，并改善临床管理。

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来源期刊

Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

6.20

自引率

2.70%

发文量

209

期刊介绍： The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.