One-pot green synthesis of N-acetylglycine from renewable N-acetyl glucosamine†

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-05-07 DOI:10.1039/D5OB00577A

Qingya Cao, Jinhang Dai, Ziting Du, Gang Chen, Fukun Li, Ting Qi, Ruiqi Wang, Weilu Wang, Jun Zhao and Chenxi Huang

引用次数: 0

Abstract

One-pot synthesis of N-acetylglycine from N-acetyl glucosamine using a combination of heterogeneous MgO and Ag₂O was demonstrated, achieving an enhanced yield of 29% in water under mild conditions. Compared to traditional methods, environment unfriendly Strecker reactions are avoided. Experimental and DFT results revealed that 2-acetamido acetaldehyde was identified as the main intermediate. This work provides an example for self-nitrogen supplied synthesis of valuable organonitrogen compounds from chitin biomass.

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可再生n -乙酰氨基葡萄糖一锅绿色合成n -乙酰氨基甘氨酸。

在温和条件下，采用多相氧化镁和Ag2O一锅法从n -乙酰氨基葡萄糖胺中合成n -乙酰氨基甘氨酸，收率提高29%。与传统方法相比，避免了对环境不友好的Strecker反应。实验和DFT结果表明，2-乙酰氨基乙醛被确定为主要中间体。本研究为甲壳素生物质自供氮合成有价有机氮化合物提供了一个范例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.