The correlation of apolipoprotein B and apolipoprotein A1 with metabolic dysfunction-associated steatotic liver disease in children and adolescents with obesity.

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2025-05-06 DOI:10.1111/ijpo.70017

Xiao-Yan Shi, Ya-Kun Liu, Yan Chen, Zhi-Ying Jiang, Meng-Xuan Ye, Jian Wang

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引用次数: 0

Abstract

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a prevalent liver condition in children and teenagers with obesity. Unfortunately, there is no standardized treatment.

Objective: To examine the connection between apolipoprotein B (apoB), apolipoprotein A1 (apoA1), and the apoB/apoA1 ratio with the occurrence of MASLD in this population.

Methods: A retrospective study was made on children and adolescents with obesity in a children's hospital between the period 2020 and 2022. Anthropometric data, ultrasound results, and blood biochemistry were analysed to assess the connection between apoB, apoA1, and the presence of MASLD.

Results: Of the 916 participants included, 313 were diagnosed with MASLD. The level of serum apoB reflected a substantial dose-response correlation with the odds of having MASLD. When apoB levels exceeded the 50th percentile, the risk increased significantly, and at the 95th percentile, the odds were 4.83 times higher than at the 50th percentile (95% CI: 2.02-11.56). The ratio of apoB/apoA1 at the 95th percentile was connected to a 2.41-fold higher prevalence compared to the 50th percentile (95% CI: 1.33-4.37). No significant correlation was found between the levels of apoA1 and MASLD prevalence.

Conclusion: Elevated levels of apoB and the apoB/apoA1 ratio have been strongly connected to increased MASLD prevalence in children and adolescents with obesity; hence, signifying their potential usefulness as biomarkers for early detection and intervention.

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载脂蛋白B和载脂蛋白A1与肥胖儿童和青少年代谢功能障碍相关的脂肪变性肝病的相关性

背景：代谢功能障碍相关的脂肪变性肝病（MASLD）已成为儿童和青少年肥胖的一种普遍肝脏疾病。不幸的是，没有标准化的治疗方法。目的：探讨载脂蛋白B （apoB）、载脂蛋白A1 （apoA1）及载脂蛋白/载脂蛋白A1比值与该人群MASLD发生的关系。方法：对某儿童医院2020 ~ 2022年收治的肥胖儿童和青少年进行回顾性研究。对人体测量数据、超声结果和血液生化进行分析，以评估载脂蛋白ob、载脂蛋白a1与MASLD存在之间的联系。结果：在纳入的916名参与者中，313名被诊断为MASLD。血清载脂蛋白水平反映了与MASLD发生率的剂量-反应相关性。当载脂蛋白ob水平超过第50百分位时，风险显著增加，在第95百分位时，风险是第50百分位的4.83倍（95% CI: 2.02-11.56）。与第50百分位相比，第95百分位的apoB/apoA1比值与2.41倍的患病率相关（95% CI: 1.33-4.37）。apoA1水平与MASLD患病率之间未发现显著相关性。结论：apoB和apoB/apoA1比值的升高与肥胖儿童和青少年MASLD患病率的增加密切相关；因此，表明它们作为早期检测和干预的生物标志物的潜在用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.