Harnessing the Power of Natural Products for Targeted Protein Degradation.

IF 10.9 1区医学 Q1 CHEMISTRY, MEDICINAL

Medicinal Research Reviews Pub Date : 2025-04-30 DOI:10.1002/med.22113

Bo Zhu, Zheng Wu, Yiwen Shou, Kaili Zhao, Qinpei Lu, Jiang-Jiang Qin, Hongwei Guo

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引用次数: 0

Abstract

Natural products have garnered significant attention due to their complex chemical structures and remarkable pharmacological activities. With inherent recognition capabilities for protein surfaces, natural products serve as ideal candidates for designing proteolysis-targeting chimeras (PROTACs). The utilization of natural products in PROTAC development offers distinct advantages, including their rich chemical diversity, multitarget activities, and sustainable sourcing. This comprehensive review explores the vast potential of harnessing natural products in PROTAC research. Moreover, the review discusses the application of natural degradant technology, which involves utilizing natural product-based compounds to selectively degrade disease-causing proteins, as well as the implementation of computer-aided drug design (CADD) technology in identifying suitable targets for degradation within the realm of natural products. By harnessing the power of natural products and leveraging computational tools, PROTACs derived from natural products have the potential to revolutionize drug discovery and provide innovative therapeutic interventions for various diseases.

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利用天然产物的力量进行靶向蛋白质降解。

天然产物因其复杂的化学结构和显著的药理活性而备受关注。天然产物具有固有的蛋白质表面识别能力，是设计蛋白水解靶向嵌合体（PROTACs）的理想候选者。在PROTAC开发中利用天然产品具有明显的优势，包括其丰富的化学多样性，多目标活动和可持续的采购。这篇全面的综述探讨了在PROTAC研究中利用天然产物的巨大潜力。此外，本文还讨论了自然降解技术的应用，包括利用基于天然产物的化合物选择性地降解致病蛋白质，以及在天然产物领域内确定合适降解靶点的计算机辅助药物设计（CADD）技术的实施。通过利用天然产物的力量和利用计算工具，源自天然产物的PROTACs有可能彻底改变药物发现，并为各种疾病提供创新的治疗干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicinal Research Reviews 医学-药学

CiteScore

29.30

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.